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Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $32 | In Stock | |
25 mg | $50 | In Stock | |
50 mg | $72 | In Stock | |
100 mg | $98 | In Stock | |
500 mg | $278 | In Stock |
Description | Cystamine (2,2'-Disulfanediyldiethanamine) is an inhibitor of transglutaminase and inhibits caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used in studies about Huntington's diseases. |
Targets&IC50 | Caspase-3:23.6 μM |
In vitro | In human neuroblastoma SH-SY5Y cells, Cystamine inhibits the MG132-mediated and H2O2-mediated activation of caspase-3 in a concentration-dependent manner. Cystamine (250 μM) robustly results in an increasement of the glutathione level[1]. |
In vivo | In R6/2 transgenic HD mice, oral and intraperitoneal administration of Cystamine (112-225 mg/kg) reduces the levels of transglutaminase and N(Sigma)-(gamma-L-glutamyl)-L-lysin. Cystamine extends survival and improves body weight and motor performance[2]. |
Alias | 2,2'-Disulfanediyldiethanamine |
Molecular Weight | 152.28 |
Formula | C4H12N2S2 |
Cas No. | 51-85-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 90.0 mg/mL (591.0 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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