Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ZM223 is an inhibitor of NEDD8 activating enzyme (NAE).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 195.00 | |
2 mg | In stock | $ 293.00 | |
5 mg | In stock | $ 448.00 | |
10 mg | In stock | $ 658.00 | |
25 mg | In stock | $ 987.00 | |
50 mg | In stock | $ 1,380.00 | |
100 mg | In stock | $ 1,890.00 | |
500 mg | In stock | $ 3,780.00 |
Description | ZM223 is an inhibitor of NEDD8 activating enzyme (NAE). |
In vitro | ZM223 (0.1-1 μM) inhibits cell growth with IC50s of 100 and 122 nM in HCT-116 and U-2OS cancer cells, respectively. ZM223 (0.1-1 μM) dose-dependently reduces the level of NEDD8 and accumulation of the UBC12 protein thereby reducing the subsequent NEDD8-UBC12 complex[1]. |
Synonyms | ZM-223 |
Molecular Weight | 502.53 |
Formula | C23H17F3N4O2S2 |
CAS No. | 2031177-48-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (159.2 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
ZM223 2031177-48-5 Ubiquitination E1/E2/E3 Enzyme ZM 223 ZM-223 inhibitor inhibit