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[D-Trp8]-γ-MSH acetate(321351-81-9 free base)

Catalog No. TP1893L1   CAS TP1893L1

Selective melanocortin 3 (MC3) receptor agonist (IC50 values are 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors respectively). Displays anti-inflammatory efficacy.

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[D-Trp8]-γ-MSH acetate(321351-81-9 free base) Chemical Structure
[D-Trp8]-γ-MSH acetate(321351-81-9 free base), CAS TP1893L1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 239.00
5 mg In stock $ 539.00
10 mg In stock $ 778.00
25 mg In stock $ 1,180.00
50 mg In stock $ 1,590.00
100 mg In stock $ 2,180.00
500 mg In stock $ 4,360.00
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Purity: 100%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Selective melanocortin 3 (MC3) receptor agonist (IC50 values are 6.7, 340 and 600 nM for human MC3, MC5 and MC4 receptors respectively). Displays anti-inflammatory efficacy.
Targets&IC50 melanocortin 3 (MC3):6.7 Nm, melanocortin-5 receptor (MC5R):340 Nm, melanocortin-4 receptor (MC4R):600 nM
Molecular Weight 1630.82
Formula C76H103N21O18S
CAS No. TP1893L1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: Insoluble

TargetMolReferences and Literature

1. Grieco et al (2000) D-amino acid scan of γ-melanocyte-stimulating hormone: importance of Trp8 on human MC3 receptor selectivity. J.Med.Chem. 43 4998 PMID: 2. Getting et al (2006) [D-Trp8]-γ-Melanocyte-stimulating-hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse). Mol.Pharmacol. 70 1850 PMID: 3. Patel et al (2010) Anti-inflammatory and antiosteoclastogenesis properties of endogenous melanocortin receptor type 3 in experimental arthritis. FASEB J. 24 4835 PMID:

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Keywords

[D-Trp8]-γ-MSH acetate(321351-81-9 free base) TP1893L1 GPCR/G Protein Neuroscience Melanocortin Receptor [D Trp8] γ MSH acetate(321351 81 9 free base) [D-Trp8]-r-MSH acetate(321351-81-9 free base) [D-Trp8]-gamma-MSH acetate(321351-81-9 free base) [DTrp8]γMSH acetate(321351819 free base) [D-Trp-8]-γ-MSH acetate(321351-81-9 free base) inhibitor inhibit

 

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