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Abelacimab
🥰Excellent
Catalog No. T76894Cas No. 2098724-83-3
Alias MAA868, MAA 868
Abelacimab (MAA868), a fully human IgG1 monoclonal antibody that binds to and blocks the activation of FXI, is an anticoagulant used in the study of thromboembolic diseases.
Abelacimab
Abelacimab
🥰Excellent
Purity: 95%
Catalog No. T76894Alias MAA868, MAA 868Cas No. 2098724-83-3
Abelacimab (MAA868), a fully human IgG1 monoclonal antibody that binds to and blocks the activation of FXI, is an anticoagulant used in the study of thromboembolic diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $228 | In Stock | |
| 5 mg | $629 | In Stock | |
| 10 mg | $993 | In Stock | |
| 25 mg | $1,470 | In Stock | |
| 50 mg | $1,980 | In Stock |
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Concentration:11.13 mg/mL
Purity:95%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Abelacimab (MAA868), a fully human IgG1 monoclonal antibody that binds to and blocks the activation of FXI, is an anticoagulant used in the study of thromboembolic diseases. |
| In vitro | Abelacimab prolonged clotting time and decreased human plasma thrombin levels in a concentration-dependent manner over a concentration range of 0.0001 to 1 μM. [1] |
| In vivo | Subcutaneous injections of 3-30 mg/kg Abelacimab , days 1, 85, and 114, demonstrated potent and long-lasting anticoagulant effects in crab-eating monkeys, significantly prolonged the aPTT, and had a favorable safety profile, with no significant signs of toxicity or bleeding observed. In addition, intravenous, 0.6 mg/kg Abelacimab also demonstrated excellent anticoagulant activity in the FXI-/- C57BL/6 mouse model of ferric chloride-induced thrombosis, preventing carotid artery occlusion. [1] |
| Alias | MAA868, MAA 868 |
| Cas No. | 2098724-83-3 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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