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Adenosine Dialdehyde (Periodate-oxidized adenosine) is a purine nucleoside analogue. Adenosine Dialdehyde is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $50 | In Stock | |
10 mg | $64 | In Stock | |
25 mg | $95 | In Stock | |
50 mg | $166 | In Stock | |
100 mg | $249 | In Stock | |
200 mg | $373 | In Stock | |
500 mg | $628 | In Stock | |
1 mL x 10 mM (in DMSO) | $55 | In Stock |
Description | Adenosine Dialdehyde (Periodate-oxidized adenosine) is a purine nucleoside analogue. Adenosine Dialdehyde is a potent inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) (Ki=3.3 nM). Adenosine Dialdehyde exhibits potent anti-tumor activity in vivo. |
In vitro | Adenosine dialdehyde suppresses MNB cell replication in tissue culture (1.5 μM, 50% inhibition) [1]. |
In vivo | Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; two 7-day periods interspersed by a 7-day drug free interval( minipump infusion))increases mean life span 80% in diluent treated controls (controls, 21.3 days; AD treated 38.4 days) in mice. Adenosine dialdehyde (subcutaneous injection; 1.5-2.5 mg/kg; infused over a 7-day period ( minipump infusion)) significantly increases the mean life span of tumor bearing mice from 20.9 days in diluent treated controls to 35.3 days in AD treated animals. Adenosine dialdehyde (subcutaneous injection; 2-3 mg/kg; infused over a 7-day period ( minipump infusion)) does not exhibit any hematopoietic toxicity in mice, and it can significantly suppress murine neuroblastoma tumor growth with little systemic toxicity[2]. |
Alias | Periodate-oxidized adenosine, Adenox, Adenosinedialdehyde, Adenosine, periodate oxidized |
Molecular Weight | 265.23 |
Formula | C10H11N5O4 |
Cas No. | 34240-05-6 |
Smiles | C(OC(CO)C=O)(C=O)N1C=2C(N=C1)=C(N)N=CN2 |
Relative Density. | 1.69 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45 mg/mL (169.66 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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