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AGX51

AGX51 is an antagonist of inhibitor of DNA binding (ID) proteins. AGX51 treatment lead to pan-Id degradation, cell cycle arrest, and cell death.

Catalog No. T10268Cas No. 330834-54-3

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Purity:99.85%

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COA HNMR HPLC

AGX51

Catalog No. T10268Cas No. 330834-54-3

AGX51 is an antagonist of inhibitor of DNA binding (ID) proteins. AGX51 treatment lead to pan-Id degradation, cell cycle arrest, and cell death.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$118	In Stock
5 mg	$291	In Stock
10 mg	$457	In Stock
25 mg	$725	In Stock
50 mg	$995	In Stock
100 mg	$1,380	In Stock
1 mL x 10 mM (in DMSO)	$319	In Stock

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Product Introduction

Bioactivity

Description	AGX51 is an antagonist of inhibitor of DNA binding (ID) proteins. AGX51 treatment lead to pan-Id degradation, cell cycle arrest, and cell death.
In vitro	AGX51 inhibits the Id1-E47 interaction. AGX51 is well-tolerated in mice and phenocopies the genetic loss of Id expression in AMD and ROP models by inhibiting retinal neovascularization. AGX51 may have utility in the management of multiple diseases[1].

Chemical Properties

Molecular Weight	431.52
Formula	C₂₇H₂₉NO₄
Cas No.	330834-54-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

Ethanol: 95 mg/mL (220.15 mM), Sonication is recommended.

DMSO: 95 mg/mL (220.15 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3174 mL	11.5869 mL	23.1739 mL	115.8695 mL
5 mM	0.4635 mL	2.3174 mL	4.6348 mL	23.1739 mL
10 mM	0.2317 mL	1.1587 mL	2.3174 mL	11.5869 mL
20 mM	0.1159 mL	0.5793 mL	1.1587 mL	5.7935 mL
50 mM	0.0463 mL	0.2317 mL	0.4635 mL	2.3174 mL
100 mM	0.0232 mL	0.1159 mL	0.2317 mL	1.1587 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

ubiquitinAGX-51AGX51AGX 51Inhibitoranti-tumorTNBCinhibit