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Akt/NF-κB/MAPK-IN-1
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Catalog No. T78838
Akt/NF-κB/MAPK-IN-1 (compound 2m) is a potent, orally active inhibitor of NO with an IC50 of 7.70 μM and low toxicity, exhibiting anti-inflammatory effects by blocking the Akt/NF-κB and MAPK signaling pathways [1].
Akt/NF-κB/MAPK-IN-1
Akt/NF-κB/MAPK-IN-1
😃Good
Catalog No. T78838
Akt/NF-κB/MAPK-IN-1 (compound 2m) is a potent, orally active inhibitor of NO with an IC50 of 7.70 μM and low toxicity, exhibiting anti-inflammatory effects by blocking the Akt/NF-κB and MAPK signaling pathways [1].
| Pack Size | Price | Availability | Quantity |
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| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Akt/NF-κB/MAPK-IN-1 (compound 2m) is a potent, orally active inhibitor of NO with an IC50 of 7.70 μM and low toxicity, exhibiting anti-inflammatory effects by blocking the Akt/NF-κB and MAPK signaling pathways [1]. |
| In vitro | Akt/NF-κB/MAPK-IN-1 (compound 2m) at concentrations of 0 to 20 μM over 24 hours significantly reduced TNF-α, IL-1β, IL-6, and PGE2 levels, and downregulated iNOS and COX-2 expression in LPS (10 ng/mL)-stimulated RAW264.7 cells. Additionally, it inhibited p38, ERK, and JNK phosphorylation in LPS-induced RAW264.7 cells [1]. |
| In vivo | Akt/NF-κB/MAPK-IN-1 (compound 2m), administered orally at 10-20 mg/kg for 7 consecutive days, alleviates LPS-induced inflammatory disease in mice [1]. |
| Molecular Weight | 604.86 |
| Formula | C38H56N2O4 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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