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Aligeron
🥰Excellent
Catalog No. T36619Cas No. 70713-45-0
Aligeron, a non-selective prostaglandin (PG) antagonist, inhibits PGF2α- and PGE2-induced blood pressure decreases in cats and can prevent PGF2α-induced diarrhea in mice and PGE2-induced paw edema in rats. Additionally, Aligeron is recognized for its antioxidant-protective effect against vascular complications.
Aligeron
🥰Excellent
Purity: 100%
Catalog No. T36619Cas No. 70713-45-0
Aligeron, a non-selective prostaglandin (PG) antagonist, inhibits PGF2α- and PGE2-induced blood pressure decreases in cats and can prevent PGF2α-induced diarrhea in mice and PGE2-induced paw edema in rats. Additionally, Aligeron is recognized for its antioxidant-protective effect against vascular complications.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $700 | In Stock | |
| 5 mg | $1,800 | In Stock |
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Aligeron, a non-selective prostaglandin (PG) antagonist, inhibits PGF2α- and PGE2-induced blood pressure decreases in cats and can prevent PGF2α-induced diarrhea in mice and PGE2-induced paw edema in rats. Additionally, Aligeron is recognized for its antioxidant-protective effect against vascular complications. |
| In vitro | Aligeron demonstrates a wide-ranging spectrum of antagonistic activity against various spasmogens in diverse isolated organs. In experiments conducted on the isolated perfused rabbit artery, the antagonistic effects of Aligeron against the vasoconstrictor impacts of noradrenaline and adrenaline are evident.[1]] The effect of Aligeronin in vitro lacks selectivity and is probably due to interference with the action of Ca2+.[3] |
| In vivo | Aligeron(5 mg/kg; i.v.) increases cortical resistance to hypoxia and accelerates the recovery of cortical bioelectrical activity In hypoventilation hypoxia. Aligerons show a protective effect in KCl- and AMP-induced depressions manifested, And show a decrease in the degree and duration of the depression.[2] |
| Molecular Weight | 292.42 |
| Formula | C20H24N2 |
| Cas No. | 70713-45-0 |
| Smiles | C=CCN1CCN(CC1)C(C=2C=CC=CC2)C=3C=CC=CC3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: Soluble |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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