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AMPA receptor modulator-4
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Catalog No. T78971Cas No. 2917551-59-6
AMPA Receptor Modulator-4, a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BTD), serves as an orally active positive allosteric modulator of the AMPA receptors (AMPAR PAMs). This compound is capable of crossing the blood-brain barrier and has been found to enhance cognitive performance and working memory in mice [1].
AMPA receptor modulator-4
😃Good
Catalog No. T78971Cas No. 2917551-59-6
AMPA Receptor Modulator-4, a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BTD), serves as an orally active positive allosteric modulator of the AMPA receptors (AMPAR PAMs). This compound is capable of crossing the blood-brain barrier and has been found to enhance cognitive performance and working memory in mice [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | AMPA Receptor Modulator-4, a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BTD), serves as an orally active positive allosteric modulator of the AMPA receptors (AMPAR PAMs). This compound is capable of crossing the blood-brain barrier and has been found to enhance cognitive performance and working memory in mice [1]. |
| In vitro | AMPA receptor modulator-4 (compound 15e) exhibits a pEC50 value of 5.66 for the calcium influx induced by 1 mM glutamate in HEK293 cells stably expressing the GluA2(Q) subunit [1]. The effective concentration of AMPA receptor modulator-4 required to double the response (EC2x) is 2.1 μM in FlipR and 1.5 μM in FDSS assays [1]. |
| In vivo | AMPA receptor modulator-4 administered intraperitoneally at a dose of 10 mg/kg increased the duration of Long-Term Potentiation (LTP) in rats [1]. Oral administration of the compound at 1 and 3 mg/kg, one hour prior to three treatment sessions, significantly enhanced cognitive abilities in CD1 mice [1]. The modulator, given via intraperitoneal injection at 0.03, 0.1, and 0.3 mg/kg, improved spontaneous alternation behavior and working memory performance in C57BL/6 mice [1]. Additionally, AMPA receptor modulator-4, at 30 and 100 mg/kg orally, exhibited anticonvulsant effects in NMRI mice [1]. |
| Molecular Weight | 290.74 |
| Formula | C11H12ClFN2O2S |
| Cas No. | 2917551-59-6 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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