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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $143 | 35 days | |
5 mg | $633 | 35 days | |
10 mg | $1,120 | 35 days |
Description | AMX12006, a potent and selective EP4 antagonist, exhibits cytotoxic and antitumor activity, demonstrating oral activity with an IC50 of 4.3 nM [1]. |
Targets&IC50 | EP4 (human):4.3 nM |
In vitro | AMX12006, at concentrations ranging from 0 to 100 µM, exhibits cytotoxic effects with IC50 values of 46.73 µM for MCF-7, 79.47 µM for 4T1, over 100 µM for HCA-7, 41.39 µM for CT-26 WT, and over 100 µM for LLC cells [1]. |
In vivo | AMX12006, administered orally at doses of 75 and 150 mg/kg once daily for 11 days, demonstrated dose-dependent antitumor activity [1]. |
Molecular Weight | 481.47 |
Formula | C26H22F3N3O3 |
Cas No. | 2639775-01-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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