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AMX12006
AMX12006
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AMX12006
Catalog No. T78710Cas No. 2639775-01-0
AMX12006, a potent and selective EP4 antagonist, exhibits cytotoxic and antitumor activity, demonstrating oral activity with an IC50 of 4.3 nM [1].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $143 | 35 days | |
| 5 mg | $633 | 35 days | |
| 10 mg | $1,120 | 35 days |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AMX12006, a potent and selective EP4 antagonist, exhibits cytotoxic and antitumor activity, demonstrating oral activity with an IC50 of 4.3 nM [1]. |
| Targets&IC50 | EP4 (human):4.3 nM |
| In vitro | AMX12006, at concentrations ranging from 0 to 100 µM, exhibits cytotoxic effects with IC50 values of 46.73 µM for MCF-7, 79.47 µM for 4T1, over 100 µM for HCA-7, 41.39 µM for CT-26 WT, and over 100 µM for LLC cells [1]. |
| In vivo | AMX12006, administered orally at doses of 75 and 150 mg/kg once daily for 11 days, demonstrated dose-dependent antitumor activity [1]. |
| Molecular Weight | 481.47 |
| Formula | C26H22F3N3O3 |
| Cas No. | 2639775-01-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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