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Antalarmin
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Catalog No. T70433Cas No. 157284-96-3
Antalarmin is a selective and potent corticotropin-releasing factor receptor 1 (CRHR1) antagonist that crosses the blood-brain barrier and blocks CRF activation and carrageenan-induced subcutaneous inflammation in rats.
Antalarmin
😃Good
Catalog No. T70433Cas No. 157284-96-3
Antalarmin is a selective and potent corticotropin-releasing factor receptor 1 (CRHR1) antagonist that crosses the blood-brain barrier and blocks CRF activation and carrageenan-induced subcutaneous inflammation in rats.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 1-2 weeks | |
| 50 mg | $1,980 | 1-2 weeks | |
| 100 mg | $2,500 | 1-2 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Antalarmin is a selective and potent corticotropin-releasing factor receptor 1 (CRHR1) antagonist that crosses the blood-brain barrier and blocks CRF activation and carrageenan-induced subcutaneous inflammation in rats. |
| Targets&IC50 | CRHR1:2.7 nM (Ki) |
| In vitro | Antalarmin (100 nM; 48 hours) treatment was able to block CRF-induced increases in PKAIIβ levels in hippocampal neurons derived from Tg2576 mice[2]. |
| In vivo | In the chronic mild stress model using BALB/cByJIco male mice, intraperitoneal administration of Antalarmin (10 mg/kg; once daily for 4 weeks) was able to significantly improve the physical state of the mice[1]. |
| Molecular Weight | 378.55 |
| Formula | C24H34N4 |
| Cas No. | 157284-96-3 |
| Smiles | N=1C(=NC(=C2C1N(C=3C(=CC(=CC3C)C)C)C(=C2C)C)N(CC)CCCC)C |
Storage & Solubility Information
| Storage | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (52.83 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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