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Arctiin

🥰Excellent
Catalog No. T2766Cas No. 20362-31-6
Alias NSC 315527, Arctii, Arctigenin-4-glucoside

Arctiin (Arctigenin-4-glucoside) acts on an agonists of the adiponectin receptor 1 with anti-cancer effects.

Arctiin

Arctiin

🥰Excellent
Purity: 99.81%
Catalog No. T2766Alias NSC 315527, Arctii, Arctigenin-4-glucosideCas No. 20362-31-6
Arctiin (Arctigenin-4-glucoside) acts on an agonists of the adiponectin receptor 1 with anti-cancer effects.
Pack SizePriceAvailabilityQuantity
25 mg32 €In Stock
50 mg45 €In Stock
100 mg64 €In Stock
1 mL x 10 mM (in DMSO)50 €In Stock
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Purity:99.81%
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Product Introduction

Bioactivity
Description
Arctiin (Arctigenin-4-glucoside) acts on an agonists of the adiponectin receptor 1 with anti-cancer effects.
In vitro
Arctiin induces growth inhibition and dephosphorylates the tumor-suppressor retinoblastoma protein in human immortalized keratinocyte HaCaT cells. The growth inhibition caused by arctiin is associated with the downregulation of cyclin D1 protein expression. The arctiin-induced suppression of cyclin D1 protein expression occurs in various types of human tumor cells, including osteosarcoma, lung, colorectal, cervical and breast cancer, melanoma, transformed renal cells and prostate cancer[1].
In vivo
Arctiin has anti-cancer properties in animal models. arctiin has a remarkable anti-tumor-promoting effect as seen in a two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[α]anthracene(DMBA) as an initiator and 12-Otetradecanoyl phorbol-13-acetate (TPA) as a promoter by topical and oral administration. It also has a protective effect on 2-amino-1-methyl-6- phenylimidazo[4,5-β]pyridine (PhIP)-induced carcinogenesis particularly in the mammary gland during the promotion period[1]. Arctiin is orally effective against either IFV-inoculated normal or 5-fluorouracil (5-FU)-treated mice[3].
Cell Research
HaCaT cells are plated at 1×105 cells in 25-mm-diameter dishes. Twenty-four hours after plating, various concentrations of arctiin are added to the culture medium. From the first to the third day after plating, the number of viable cells is counted by the trypan blue dye exclusion test.(Only for Reference)
AliasNSC 315527, Arctii, Arctigenin-4-glucoside
Chemical Properties
Molecular Weight534.55
FormulaC27H34O11
Cas No.20362-31-6
SmilesCOc1ccc(C[C@H]2COC(=O)[C@@H]2Cc2ccc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c(OC)c2)cc1OC
Relative Density.1.363 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 37 mg/mL (69.2 mM)
Ethanol: 93 mg/mL (174 mM)
DMSO: 50 mg/mL (93.54 mM)
Solution Preparation Table
H2O/DMSO/Ethanol
1mg5mg10mg50mg
1 mM1.8707 mL9.3537 mL18.7073 mL93.5366 mL
5 mM0.3741 mL1.8707 mL3.7415 mL18.7073 mL
10 mM0.1871 mL0.9354 mL1.8707 mL9.3537 mL
20 mM0.0935 mL0.4677 mL0.9354 mL4.6768 mL
50 mM0.0374 mL0.1871 mL0.3741 mL1.8707 mL

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