Shopping Cart
- Remove All
Your shopping cart is currently empty
ARD-2585
Catalog No. T74141Cas No. 2757422-79-8
Alias ARD2585
ARD-2585 is an orally active and selective androgen receptor PROTAC degrader with anticancer activity for the study of prostate cancer.
ARD-2585
Catalog No. T74141Alias ARD2585Cas No. 2757422-79-8
ARD-2585 is an orally active and selective androgen receptor PROTAC degrader with anticancer activity for the study of prostate cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $333 | Backorder | |
| 5 mg | $795 | Backorder | |
| 10 mg | $1,280 | Backorder | |
| 25 mg | $2,530 | Backorder | |
| 50 mg | $3,970 | Backorder |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "ARD-2585"
Flutamide
Cited
SCH 13521
T048913311-84-7
Flutamide (SCH 13521) is an antiandrogen with about the same potency as cyproterone in rodent and canine species.
- $30
Size
QTY
CitedS-23
S23, (S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide
T207891010396-29-8
S-23 ((S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) is an oral selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats.
- $39
Size
QTY
Dehydroisoandrosterone 3-acetate
Prasterone acetate, DHEA acetate, Dehydroepiandrosterone acetate, Dehydroepiandrosterone 3-acetate, androstenolone acetate
T0856853-23-6
Dehydroisoandrosterone 3-acetate (Prasterone acetate) is a primary C19 steroid generated by the adrenal cortex.
- $41
Size
QTY
Allura Red AC
FD&C RED NO. 40, CI 16035, Allura Red
TN137025956-17-6
Allura Red AC (CI 16035) is a very important food azo dye used in the food, pharmaceutical, paper, cosmetic and textile industries.Allura Red AC promotes susceptibility to experimental colitis via mouse intestinal serotonin.
- $50
Size
QTY
Sunset Yellow FCF
Sunset yellow, Orange Yellow S, Food Yellow 3, CI 15985
TN22452783-94-0
Sunset Yellow FCF (Sunset yellow) is an orange azo dye with pH-dependent absorbance.Sunset Yellow FCF is used in food, cosmetics and pharmaceuticals.It is used as a colorant food additive in many food products.They may be cytotoxic and genotoxic, so care must be taken when using these materials as food additives.
- $41
Size
QTY
Octinoxate
Octyl methoxycinnamate, Octyl 4-methoxycinnamate, ethylhexyl methoxycinnamate, 2-Ethylhexyl 4-methoxycinnamate
T00735466-77-3
Octyl 4-methoxycinnamate is an organic compound that absorbs UV-B rays from the sun, protects the skin from damage, and can also be used to minimize the appearance of scars and is commonly used in cosmetics such as sunscreens and lipsticks.Octinoxate has androgenic and estrogenic effects.
- $41
Size
QTY
Ostarine
MK-2866, GTX-024, Enobosarm
T2408841205-47-8
Ostarine (MK-2866) is a non-steroidal agent with anabolic activity. Selective androgen receptor modulator (SARM) GTx-024 is designed to work like testosterone, thus promoting and/or maintaining libido, fertility, prostate growth, and muscle growth and strength. Mimicking testosterone's action, this agent may increase lean body mass, thereby ameliorating muscle wasting in the hypermetabolic state of cancer cachexia.
- $36
Size
QTY
ARV-471
Vepdegestrant
T397102229711-68-4In house
Vepdegestrant (ARV-471) is an estrogen receptor (ER) α PROTAC molecule that degrades ER in ER-positive breast cancer cell lines with a DC50 of approximately 1 nM. It can reduce the expression of classically regulated ER target genes and inhibit the growth of ER-dependent cell lines (including those expressing ESR1 variants, such as Y537S and D538G) by degrading ER.
- $265
Size
QTY
Bicalutamide
ICI-176334
T038090357-06-5
Bicalutamide (ICI-176334), a synthetic, nonsteroidal antiandrogen, competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens.
- $32
Size
QTY
Bavdegalutamide Cited
ARV-110
T222632222112-77-6
Bavdegalutamide (ARV-110) is an oral protein degrader that specifically binds to AR and mediates its degradation. Bavdegalutamide can degrade clinically relevant mutant AR proteins, maintain activity in a high androgen environment, and has an acceptable safety profile.
- $85
Size
QTY
CiteddBET6 Cited
T51301950634-92-0
dBET6 is a selective and cell-permeable degrader of BET based on PROTAC (IC50: 14 nM). It has antitumor activity.
- $48
Size
QTY
CitedAdrenosterone
Reichstein's substance G, 11-oxoandrostenedione, 11-ketoandrostenedione
T2207382-45-6
Adrenosterone (11-ketoandrostenedione) is a steroid hormone isolated from the adrenal cortex.
- $39
Size
QTY
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | ARD-2585 is an orally active and selective androgen receptor PROTAC degrader with anticancer activity for the study of prostate cancer. |
| Targets&IC50 | VCaP cell:1.5 nM, LNCaP AR+ cell:16.2 nM |
| In vitro | ARD-2585 is effective in reducing the AR protein level at the 3 and 24 h time-points by 78% and 60% at the 6 h time-point. ARD-2585 achieves picomolar DC50 values and >98% of Dmax in the VCaP cell line with a wild-type AR and in the LNCaP cell line carrying a T878A-mutated AR mutant. ARD-2585 potently inhibits cell growth with IC50 values of 1.5 nM and 16.2 nM in the VCaP and LNCaP AR+ prostate cancer cell lines. [1] |
| In vivo | At the end of the treatment (day 37), 20 and 40 mg/kg ARD-2585 inhibits tumor growth by 54.9, 74.3, and 65.9%. ARD-2585 effectively reduces AR protein the VCaP xenograft tumor tissue in mice and inhibits VCaP tumor growth. [1] |
| Alias | ARD2585 |
| Molecular Weight | 763.28 |
| Formula | C41H43ClN8O5 |
| Cas No. | 2757422-79-8 |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL(104.81 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy ARD-2585 | purchase ARD-2585 | ARD-2585 cost | order ARD-2585 | ARD-2585 chemical structure | ARD-2585 in vivo | ARD-2585 in vitro | ARD-2585 formula | ARD-2585 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.