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ARD-266
🥰Excellent
Catalog No. T13552Cas No. 2666951-70-6
Alias ARD266
ARD-266 is a PROTAC degrader based on the von Hippel-Lindau E3 ligase, inducing the degradation of AR proteins, and can be used in prostate cancer research.
ARD-266
🥰Excellent
Catalog No. T13552Alias ARD266Cas No. 2666951-70-6
ARD-266 is a PROTAC degrader based on the von Hippel-Lindau E3 ligase, inducing the degradation of AR proteins, and can be used in prostate cancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $696 | In Stock | |
| 5 mg | $1,530 | In Stock | |
| 10 mg | $2,480 | In Stock | |
| 25 mg | $3,690 | In Stock | |
| 50 mg | $4,980 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | ARD-266 is a PROTAC degrader based on the von Hippel-Lindau E3 ligase, inducing the degradation of AR proteins, and can be used in prostate cancer research. |
| In vitro | ARD-266 (100 nM; 1-24 hours; LNCaP and VCaP cells) treatment effectively reduces the AR protein level within 3 h and achieves near-complete AR elimination with a 6 h treatment in the LNCaP cells. ARD-266 (1-10000 nM; 24 hours; LNCaP cells) treatment effectively suppresses the expression of PSA, TMPRSS2, and FKBP5 genes in a dose-dependent manner and is capable of reducing the mRNA levels of PSA, TMPRSS2, and FKBP5 genes by >50% at 10 nM in the LNCaP cell line.[1] |
| Alias | ARD266 |
| Molecular Weight | 915.51 |
| Formula | C52H59ClN6O7 |
| Cas No. | 2666951-70-6 |
| Smiles | O([C@@H]1C(C)(C)[C@@H](NC(=O)C2=CC=C(C#CC3CCN(C(C[C@H](NC(=O)[C@H]4N(C([C@H]([C@H](C)C)C=5ON=C(C)C5)=O)C[C@H](O)C4)C6=CC=CC=C6)=O)CC3)C=C2)C1(C)C)C7=CC(Cl)=C(C#N)C=C7 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (87.38 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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