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ARD-1676
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Catalog No. T79725Cas No. 2632305-36-1
ARD-1676 is an orally administered androgen receptor (AR) PROTAC degrader that combines an AR ligand with a cereblon ligand. It demonstrates AR-degrading activity both in vitro and in vivo, and effectively inhibits VCaP tumor growth in mouse xenograft models [1].
ARD-1676
😃Good
Catalog No. T79725Cas No. 2632305-36-1
ARD-1676 is an orally administered androgen receptor (AR) PROTAC degrader that combines an AR ligand with a cereblon ligand. It demonstrates AR-degrading activity both in vitro and in vivo, and effectively inhibits VCaP tumor growth in mouse xenograft models [1].
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| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | ARD-1676 is an orally administered androgen receptor (AR) PROTAC degrader that combines an AR ligand with a cereblon ligand. It demonstrates AR-degrading activity both in vitro and in vivo, and effectively inhibits VCaP tumor growth in mouse xenograft models [1]. |
| In vitro | ARD-1676 exhibits a DC50 for androgen receptor (AR) degradation at 0.1 nM in AR+ VCaP cells and 1.1 nM in LNCaP cell lines, while its IC50 values for inhibiting cell proliferation are 11.5 nM in VCaP and 2.8 nM in LNCaP cell lines [1]. |
| In vivo | ARD-1676 exhibits oral bioavailability of 67%, 44%, 31%, and 99% in mice, rats, dogs, and monkeys, respectively. It effectively reduces AR (AR) protein levels in murine VCaP tumor tissues and inhibits tumor growth in the VCaP murine xenograft tumor model [1]. |
| Molecular Weight | 788.33 |
| Formula | C44H46ClN7O5 |
| Cas No. | 2632305-36-1 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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