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Arvanil (N-Vanillylarachidonamide) is a synthetic capsaicin-amphetamine hybrid and a ligand for vanilloid receptor 1 (VR1) and cannabinoid receptor 1 (CB1), exhibiting neuroprotective activity, inhibiting spasm, and enhancing cisplatin chemotherapy sensitivity by inducing ferroptosis in HCC cells in vivo. It induces ferroptosis in liver cancer cells via binding to MICU1.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $85 | In Stock | |
10 mg | $160 | In Stock | |
50 mg | $660 | In Stock | |
100 mg | $1,140 | In Stock |
Description | Arvanil (N-Vanillylarachidonamide) is a synthetic capsaicin-amphetamine hybrid and a ligand for vanilloid receptor 1 (VR1) and cannabinoid receptor 1 (CB1), exhibiting neuroprotective activity, inhibiting spasm, and enhancing cisplatin chemotherapy sensitivity by inducing ferroptosis in HCC cells in vivo. It induces ferroptosis in liver cancer cells via binding to MICU1. |
In vitro | Arvanil directly binds to two amino acid sites of mitochondrial calcium uptake protein 1 (MICU1), Ser47 and Phe128, triggering iron death in living cells. [1] Arvanil inhibits lymphocyte proliferation and IFN-γ production. Phenotypes of activated CD4+T cells treated with Arvanil showed downregulation of T cell activation markers such as CD25, HLA-DR, and CD134/OX40. [2] |
In vivo | Arvanil (2 mg/kg, intrabitoneally injected) induced anti-hyperkinetic state in rats injected with 3-nitropropionic acid (3-NP) in bilateral striatum. [3] |
Alias | N-Vanillylarachidonamide |
Molecular Weight | 439.63 |
Formula | C28H41NO3 |
Cas No. | 128007-31-8 |
Smiles | C(NC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)C1=CC(OC)=C(O)C=C1 |
Relative Density. | 1.31g/cm3 |
Storage | store at low temperature,High Volatility | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | Ethanol: 8 mg/mL (18.2 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
Ethanol
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