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Arvanil

🥰Excellent
Catalog No. T22586Cas No. 128007-31-8
Alias N-Vanillylarachidonamide

Arvanil (N-Vanillylarachidonamide) is a synthetic capsaicin-amphetamine hybrid and a ligand for vanilloid receptor 1 (VR1) and cannabinoid receptor 1 (CB1), exhibiting neuroprotective activity, inhibiting spasm, and enhancing cisplatin chemotherapy sensitivity by inducing ferroptosis in HCC cells in vivo. It induces ferroptosis in liver cancer cells via binding to MICU1.

Arvanil

Arvanil

🥰Excellent
Purity: 100%
Catalog No. T22586Alias N-VanillylarachidonamideCas No. 128007-31-8
Arvanil (N-Vanillylarachidonamide) is a synthetic capsaicin-amphetamine hybrid and a ligand for vanilloid receptor 1 (VR1) and cannabinoid receptor 1 (CB1), exhibiting neuroprotective activity, inhibiting spasm, and enhancing cisplatin chemotherapy sensitivity by inducing ferroptosis in HCC cells in vivo. It induces ferroptosis in liver cancer cells via binding to MICU1.
Pack SizePriceAvailabilityQuantity
5 mg$85 In Stock
10 mg$160 In Stock
50 mg$660 In Stock
100 mg$1,140 In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
Arvanil (N-Vanillylarachidonamide) is a synthetic capsaicin-amphetamine hybrid and a ligand for vanilloid receptor 1 (VR1) and cannabinoid receptor 1 (CB1), exhibiting neuroprotective activity, inhibiting spasm, and enhancing cisplatin chemotherapy sensitivity by inducing ferroptosis in HCC cells in vivo. It induces ferroptosis in liver cancer cells via binding to MICU1.
In vitro
Arvanil directly binds to two amino acid sites of mitochondrial calcium uptake protein 1 (MICU1), Ser47 and Phe128, triggering iron death in living cells. [1]
Arvanil inhibits lymphocyte proliferation and IFN-γ production. Phenotypes of activated CD4+T cells treated with Arvanil showed downregulation of T cell activation markers such as CD25, HLA-DR, and CD134/OX40. [2]
In vivo
Arvanil (2 mg/kg, intrabitoneally injected) induced anti-hyperkinetic state in rats injected with 3-nitropropionic acid (3-NP) in bilateral striatum. [3]
AliasN-Vanillylarachidonamide
Chemical Properties
Molecular Weight439.63
FormulaC28H41NO3
Cas No.128007-31-8
SmilesC(NC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)C1=CC(OC)=C(O)C=C1
Relative Density.1.31g/cm3
Storage & Solubility Information
Storagestore at low temperature,High Volatility | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 8 mg/mL (18.2 mM), Sonication is recommended.
Solution Preparation Table
Ethanol
1mg5mg10mg50mg
1 mM2.2746 mL11.3732 mL22.7464 mL113.7320 mL
5 mM0.4549 mL2.2746 mL4.5493 mL22.7464 mL
10 mM0.2275 mL1.1373 mL2.2746 mL11.3732 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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