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Arvanil
🥰Excellent
Catalog No. T22586Cas No. 128007-31-8
Alias N-Vanillylarachidonamide
Arvanil (N-Vanillylarachidonamide) is a synthetic capsaicin-amphetamine hybrid and a ligand for vanilloid receptor 1 (VR1) and cannabinoid receptor 1 (CB1), exhibiting neuroprotective activity, inhibiting spasm, and enhancing cisplatin chemotherapy sensitivity by inducing ferroptosis in HCC cells in vivo. It induces ferroptosis in liver cancer cells via binding to MICU1.
Arvanil
🥰Excellent
Purity: 99.49%
Catalog No. T22586Alias N-VanillylarachidonamideCas No. 128007-31-8
Arvanil (N-Vanillylarachidonamide) is a synthetic capsaicin-amphetamine hybrid and a ligand for vanilloid receptor 1 (VR1) and cannabinoid receptor 1 (CB1), exhibiting neuroprotective activity, inhibiting spasm, and enhancing cisplatin chemotherapy sensitivity by inducing ferroptosis in HCC cells in vivo. It induces ferroptosis in liver cancer cells via binding to MICU1.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $85 | In Stock | |
| 10 mg | $160 | In Stock | |
| 50 mg | $660 | In Stock | |
| 100 mg | $1,140 | In Stock |
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Purity:99.49%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Arvanil (N-Vanillylarachidonamide) is a synthetic capsaicin-amphetamine hybrid and a ligand for vanilloid receptor 1 (VR1) and cannabinoid receptor 1 (CB1), exhibiting neuroprotective activity, inhibiting spasm, and enhancing cisplatin chemotherapy sensitivity by inducing ferroptosis in HCC cells in vivo. It induces ferroptosis in liver cancer cells via binding to MICU1. |
| In vitro | Arvanil directly binds to two amino acid sites of mitochondrial calcium uptake protein 1 (MICU1), Ser47 and Phe128, triggering iron death in living cells. [1] Arvanil inhibits lymphocyte proliferation and IFN-γ production. Phenotypes of activated CD4+T cells treated with Arvanil showed downregulation of T cell activation markers such as CD25, HLA-DR, and CD134/OX40. [2] |
| In vivo | Arvanil (2 mg/kg, intrabitoneally injected) induced anti-hyperkinetic state in rats injected with 3-nitropropionic acid (3-NP) in bilateral striatum. [3] |
| Alias | N-Vanillylarachidonamide |
| Molecular Weight | 439.63 |
| Formula | C28H41NO3 |
| Cas No. | 128007-31-8 |
| Smiles | C(NC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)C1=CC(OC)=C(O)C=C1 |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature,High Volatility | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | Ethanol: 8 mg/mL (18.2 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
Ethanol
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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