AZ505 ditrifluoroacetate

AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).

Catalog No. T10427Cas No. 1035227-44-1

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AZ505 ditrifluoroacetate

Catalog No. T10427Cas No. 1035227-44-1

AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).

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Pack Size	Price	Availability	Quantity
50 mg	Inquiry	7-10 days
100 mg	Inquiry	7-10 days

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Product Introduction

Bioactivity

Description	AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).
Targets&IC50	SMYD2:0.12 μM
In vitro	AZ505 ditrifluoroacetate is highly selective and active at submicromolar concentrations in vitro, with an IC50 of 0.12 μM for SMYD2, over 600-fold lower than its IC50 for other histone methyltransferases such as SMYD3 (IC50>83.3 μM) and DOT1L (IC50>83.3 μM) [1]. It has been nominated for ITC binding study (Kd: 0.5 μM), in contrast to the calculated Kd of 3.7 μM for the p53 substrate peptide. The binding of AZ505 ditrifluoroacetate to SMYD2 is primarily driven by entropy, suggesting hydrophobic interactions with minimal specific hydrogen bonds [2].

Chemical Properties

Molecular Weight	805.59
Formula	C₃₃H₄₀Cl₂F₆N₄O₈
Cas No.	1035227-44-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 125 mg/mL (155.17 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2413 mL	6.2066 mL	12.4133 mL	62.0663 mL
5 mM	0.2483 mL	1.2413 mL	2.4827 mL	12.4133 mL
10 mM	0.1241 mL	0.6207 mL	1.2413 mL	6.2066 mL
20 mM	0.0621 mL	0.3103 mL	0.6207 mL	3.1033 mL
50 mM	0.0248 mL	0.1241 mL	0.2483 mL	1.2413 mL
100 mM	0.0124 mL	0.0621 mL	0.1241 mL	0.6207 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

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