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AZD3458
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Catalog No. T12466Cas No. 2132961-46-5
AZD3458 is a potent and highly selective inhibitor of PI3Kγ (PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ with pIC50s of 9.1, 5.1, <4.5, and 6.5, respectively).
AZD3458
😃Good
Catalog No. T12466Cas No. 2132961-46-5
AZD3458 is a potent and highly selective inhibitor of PI3Kγ (PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ with pIC50s of 9.1, 5.1, <4.5, and 6.5, respectively).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $970 | 6-8 weeks | |
| 50 mg | $1,260 | 6-8 weeks | |
| 100 mg | $2,190 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | AZD3458 is a potent and highly selective inhibitor of PI3Kγ (PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ with pIC50s of 9.1, 5.1, <4.5, and 6.5, respectively). |
| Targets&IC50 | PI3Kα:5.1(pIC50), PI3Kβ:4.5(pIC50), PI3KC2γ:5.5(pIC50), PI3Kγ:9.1(pIC50), PI3KC2β:7.5(pIC50), PI3Kδ:6.5(pIC50), PI3KC3:5.1(pIC50), PI3KC2α:5(pIC50) |
| In vivo | AZD3458 (Compound 15) is a potent and remarkably selective PI3Kγ inhibitor with ADME properties suitable for oral administration.?Compound 15 was advanced into in vivo studies showing dose-dependent inhibition of LPS-induced airway neutrophilia in rats when administered orally. |
| Molecular Weight | 433.54 |
| Formula | C20H23N3O4S2 |
| Cas No. | 2132961-46-5 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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