Shopping Cart
- Remove All
Your shopping cart is currently empty
BACE1-IN-5
Catalog No. T10453Cas No. 2581114-83-0
BACE1-IN-5 (Compound 15), a potent β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, demonstrates significant efficacy with an IC50 of 9.1 nM for BACE1 inhibition and an impressive IC50 of 0.82 nM against cellular amyloid-β (Aβ) production. Additionally, it is engineered to enhance hERG inhibition and P-gp efflux, indicating its optimized medicinal chemistry profile [1].
BACE1-IN-5
Catalog No. T10453Cas No. 2581114-83-0
BACE1-IN-5 (Compound 15), a potent β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, demonstrates significant efficacy with an IC50 of 9.1 nM for BACE1 inhibition and an impressive IC50 of 0.82 nM against cellular amyloid-β (Aβ) production. Additionally, it is engineered to enhance hERG inhibition and P-gp efflux, indicating its optimized medicinal chemistry profile [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 10-14 weeks | |
| 50 mg | $1,980 | 10-14 weeks | |
| 100 mg | $2,500 | 10-14 weeks |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "BACE1-IN-5"
Rutin
Cited
Rutoside, Quercetin 3-O-rutinoside
T0795153-18-4
Rutin (Quercetin 3-O-rutinoside), a flavonoid, has a variety of biological activities including antiallergic, anti-inflammatory, antiproliferative, and anticarcinogenic properties.
- $36
Size
QTY
CitedDeferoxamine Mesylate Cited
DFOM, DFO, Desferrioxamine B mesylate, desferrioxamine B
T1637138-14-7
Deferoxamine Mesylate (DFOM) is an iron chelator and ferroptosis inhibitor. Deferoxamine Mesylate binds free iron into a stable complex and reduces iron accumulation. Deferoxamine Mesylate up-regulates HIF-1α levels and induces apoptosis.
- $31
Size
QTY
CitedPhytic acid potassium
Phytic acid dipotassium salt, Inositol polyphosphate dipotassium salt, Inositol hexakisphosphate dipotassium salt, Fytic Acid dipotassium salt
T5075129832-03-7
Phytic acid dipotassium salt is an endogenous metabolite that inhibits β-secretase 1 (BACE1).
- $41
Size
QTY
Tramiprosate
Homotaurine, Alzhemed, 3-Amino-1-propanesulfonic acid
T08833687-18-1
Tramiprosate (Alzhemed) is an orally active, blood-brain-barrier-crossing, naturally occurring amino acid found in a variety of red seaweeds that binds soluble Aβ and maintains it in a non-protofibrillar form.It is a GABA analog with neuroprotective, anticonvulsant, and antihypertensive activity.
- $42
Size
QTY
Notoginsenoside R1
Sanqi glucoside R1, Sanchinoside R1
T296180418-24-2
Notoginsenoside R1 (Sanchinoside R1) has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties.
- $63
Size
QTY
Geniposide
T221224512-63-8
Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activity. Geniposide has been shown to regulate Nrf2 translocation.
- $60
Size
QTY
Dihydroergocristine mesylate
DHEC (mesylate)
T1104324730-10-7
Dihydroergocristine mesylate (DHEC (mesylate))(DHEC mesylate) is the methanesulfonic acid salt of dihydroergocristine. It has been used as the for the symptomatic treatment of mental deterioration associated with cerebrovascular insufficiency and in peripheral vascular disease. Dihydroergocristine mesylate is a inhibitor of γ-secretase (GSI), , reduces the production of the Alzheimer's disease amyloid-β peptides, binds directly to γ-secretase and Nicastrin with equilibrium dissociation constants (Kd) of 25.7 nM and 9.8 μM, respectively[1]. It is also a component of ergoloid mesylate (codergocrine mesilate), a mixture of ergot alkaloid derivatives that is used as a vasodilator and has shown mild benefits in the treatment of vascular dementia. It has a role as a vasodilator agent, an alpha-adrenergic antagonist and a geroprotector. It contains a dihydroergocristine.
- $48
Size
QTY
Anle138b
T5447882697-00-9
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease
- $77
Size
QTY
BSBM7
T198926968-11-2
BSBM7 is an inhibitor of Aβ aggregation and neuronal toxicity.
- $29
Size
QTY
Ginsenoside Re
Sanchinoside Re, Panaxoside Re, Ginsenoside B2, Chikusetsusaponin Ivc
T287252286-59-6
Ginsenoside Re (Ginsenoside B2) may have properties that inhibit or prevent the growth of tumors.
- $43
Size
QTY
Auraptene
7-geranyloxycoumarin
T4115495-02-3
Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities. It inhibits leukocyte activation and induces phas
- $30
Size
QTY
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | BACE1-IN-5 (Compound 15), a potent β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, demonstrates significant efficacy with an IC50 of 9.1 nM for BACE1 inhibition and an impressive IC50 of 0.82 nM against cellular amyloid-β (Aβ) production. Additionally, it is engineered to enhance hERG inhibition and P-gp efflux, indicating its optimized medicinal chemistry profile [1]. |
| Targets&IC50 | BACE1:9.1 nM , Cellular β-Amyloid:0.82 nM |
| In vivo | Treatment with BACE1-IN-5 (Compound 15), administered orally at doses ranging from 1-3 mg/kg to male ICR mice for durations of 2-6 hours, significantly and dose-dependently decreases total amyloid-beta (Aβ) levels. At a dose of 1 mg/kg, it reduces total Aβ by 76% within 4 hours, correlating with a free brain concentration of 4.1 ng/mL (8.9 nM). This compound also exhibits a K_p,uu value of 1.3 at the 4-hour mark and a 1 mg/kg dose. When the dosage is increased to 3 mg/kg, BACE1-IN-5 achieves a maximal Aβ reduction of 87%, corresponding to a free brain concentration of 9.5 ng/mL (21 nM). |
| Molecular Weight | 461.41 |
| Formula | C18H16F5N5O2S |
| Cas No. | 2581114-83-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy BACE1-IN-5 | purchase BACE1-IN-5 | BACE1-IN-5 cost | order BACE1-IN-5 | BACE1-IN-5 chemical structure | BACE1-IN-5 in vivo | BACE1-IN-5 formula | BACE1-IN-5 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.