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Dihydroergocristine mesylate

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Purity:99.65%

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COA HNMR HPLC

Dihydroergocristine mesylate

Catalog No. T11043Cas No. 24730-10-7

Dihydroergocristine mesylate (DHEC (mesylate))(DHEC mesylate) is the methanesulfonic acid salt of dihydroergocristine. It has been used as the for the symptomatic treatment of mental deterioration associated with cerebrovascular insufficiency and in peripheral vascular disease. Dihydroergocristine mesylate is a inhibitor of γ-secretase (GSI), , reduces the production of the Alzheimer's disease amyloid-β peptides, binds directly to γ-secretase and Nicastrin with equilibrium dissociation constants (Kd) of 25.7 nM and 9.8 μM, respectively[1]. It is also a component of ergoloid mesylate (codergocrine mesilate), a mixture of ergot alkaloid derivatives that is used as a vasodilator and has shown mild benefits in the treatment of vascular dementia. It has a role as a vasodilator agent, an alpha-adrenergic antagonist and a geroprotector. It contains a dihydroergocristine.

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Pack Size	Price	Availability
1 mg	$48	In Stock
5 mg	$122	In Stock
10 mg	$197	In Stock
25 mg	$332	In Stock
50 mg	$495	In Stock
100 mg	$676	In Stock
1 mL x 10 mM (in DMSO)	$191	In Stock

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Product Introduction

Bioactivity

Description	Dihydroergocristine mesylate (DHEC (mesylate))(DHEC mesylate) is the methanesulfonic acid salt of dihydroergocristine. It has been used as the for the symptomatic treatment of mental deterioration associated with cerebrovascular insufficiency and in peripheral vascular disease. Dihydroergocristine mesylate is a inhibitor of γ-secretase (GSI), , reduces the production of the Alzheimer's disease amyloid-β peptides, binds directly to γ-secretase and Nicastrin with equilibrium dissociation constants (Kd) of 25.7 nM and 9.8 μM, respectively[1]. It is also a component of ergoloid mesylate (codergocrine mesilate), a mixture of ergot alkaloid derivatives that is used as a vasodilator and has shown mild benefits in the treatment of vascular dementia. It has a role as a vasodilator agent, an alpha-adrenergic antagonist and a geroprotector. It contains a dihydroergocristine.
In vitro	The IC50 value(2-20 μM; 24 hours) of Dihydroergocristine (DHEC) for inhibiting the activity of γ-secretase in T100 cells without affecting cell viability is 25 μM. Dihydroergocristine (2-20 μM; 24 hours) inhibits cellular Aβ production and causes a dose-dependent accumulation of carboxy-terminal fragments of APP (APP-CTFs) in HEK293 and decreases γ-secretase activity in fibroblast cells[1].
Cell Research	Dihydroergocristine (2-20 μM; 24 hours) causes a dose-dependent accumulation of carboxy-terminal fragments of APP (APP-CTFs) in HEK293 and decreases γ-secretase activity in fibroblast cells and inhibits cellular Aβ production[1].
Alias	DHEC (mesylate)

Chemical Properties

Molecular Weight	707.84
Formula	C36H45N5O8S
Cas No.	24730-10-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (84.76 mM)

H2O: 1 mg/mL (1.41 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	1.4127 mL	7.0637 mL	14.1275 mL	70.6374 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.2825 mL	1.4127 mL	2.8255 mL	14.1275 mL
10 mM	0.1413 mL	0.7064 mL	1.4127 mL	7.0637 mL
20 mM	0.0706 mL	0.3532 mL	0.7064 mL	3.5319 mL
50 mM	0.0283 mL	0.1413 mL	0.2825 mL	1.4127 mL
100 mM	0.0141 mL	0.0706 mL	0.1413 mL	0.7064 mL

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