QCA570 is an effective BET degrader based on PROTAC (IC50: 10 nM for BRD4 BD1 Protein).

SJ10542, a phenyl glutarimide (PG)-PROTAC, demonstrates potent and selective activity against JAK2/3 by exhibiting DC50 values of 14, 11, and 24 nM for JAK2, JAK3, and JAK2-fusion ALL, respectively. It employs a PG ligand for cereblon (CRBN) recruitment [1].

PZ703b is a novel BCL-XL PROTAC degrader with enhanced BCL-2 inhibition.

Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively[1].

CCT367766 is a potent, PROTAC-based, third-generation, iso-functional pirin-targeted protein degradation probe (PDP) that depletes pirin expression at low concentrations.CCT367766 has an IC50 value of 490 nM for the CRBN-DDB1 complex.CCT367766 has a good affinity for recombinant pirin and CRBN. CCT367766 has a good affinity for recombinant pirin and CRBN, with Kd values of 55 nM and 120 nM, respectively. cct367766 is a potent orally active protein that reduces the expression of pirin at low concentrations.