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BI-3663
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Catalog No. T17543Cas No. 2341740-84-7
BI-3663 is a highly selective PTK2/FAK PROTAC that utilizes cereblon ligands to hijack E3 ligases for PTK2 degradation, with an IC50 of 18 nM. It is composed of BI-4464 linked to Pomalidomide with a linker[1]. Anti-cancer.
BI-3663
😃Good
Catalog No. T17543Cas No. 2341740-84-7
BI-3663 is a highly selective PTK2/FAK PROTAC that utilizes cereblon ligands to hijack E3 ligases for PTK2 degradation, with an IC50 of 18 nM. It is composed of BI-4464 linked to Pomalidomide with a linker[1]. Anti-cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $197 | 7-10 days | |
| 5 mg | $519 | 7-10 days | |
| 10 mg | $975 | 7-10 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | BI-3663 is a highly selective PTK2/FAK PROTAC that utilizes cereblon ligands to hijack E3 ligases for PTK2 degradation, with an IC50 of 18 nM. It is composed of BI-4464 linked to Pomalidomide with a linker[1]. Anti-cancer. |
| Targets&IC50 | PTK2/FAK:18 nM (IC50) |
| In vitro | BI-3663 potently degrades PTK2 in Hep3B2.1-7 cells, and A549 cells, with pDC50s of 7.6 and 7.9, respectively[1]. |
| Molecular Weight | 917.84 |
| Formula | C44H42F3N7O12 |
| Cas No. | 2341740-84-7 |
| Relative Density. | 1.456 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 300 mg/mL (326.85 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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