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BI 7446
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Catalog No. T79313Cas No. 2767011-00-5
BI 7446 is a potent and selective cyclic dinucleotide (CDN)-based stimulator of interferon genes (STING) agonist capable of activating all five STING variants in cells, thus inducing tumor-specific immune-mediated tumor rejection. This compound is utilized in immuno-oncology research [1].
BI 7446
😃Good
Catalog No. T79313Cas No. 2767011-00-5
BI 7446 is a potent and selective cyclic dinucleotide (CDN)-based stimulator of interferon genes (STING) agonist capable of activating all five STING variants in cells, thus inducing tumor-specific immune-mediated tumor rejection. This compound is utilized in immuno-oncology research [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | 8-10 weeks | |
| 50 mg | Inquiry | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | BI 7446 is a potent and selective cyclic dinucleotide (CDN)-based stimulator of interferon genes (STING) agonist capable of activating all five STING variants in cells, thus inducing tumor-specific immune-mediated tumor rejection. This compound is utilized in immuno-oncology research [1]. |
| In vitro | BI 7446 (CDN13) at concentrations of 3 μM and 10 μM over 6 hours enhances the phosphorylation of IRF3 and TBK1 in THP1 STING wild-type cells [1]. |
| In vivo | BI 7446 (CDN13) administered intravenously at doses of 4, 12, and 36 μg with detection time points up to 25 hours exhibited high plasma clearance and a short elimination half-life in the 4T1 tumor mouse model [1]. Similarly, subcutaneous injections of BI 7446 at 0.25, 1, and 4 μg once weekly resulted in tumor regression in the EMT breast cancer mouse model and generated long-term immune memory against autologous tumor rechallenge [1]. |
| Molecular Weight | 693.52 |
| Formula | C20H22FN9O10P2S2 |
| Cas No. | 2767011-00-5 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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