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Brr2-IN-3

Brr2-IN-3 (Brr2 Inhibitor C9) is an allosteric inhibitor of the spliceosomal RNA helicase Brr2. Brr2 is implicated in autosomal-dominant retinitis pigmentosa (a group of progressive retinal degenerative disorders).

Catalog No. T22282Cas No. 2104030-82-0

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Purity:99.12%

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COA HNMR HPLC

Brr2-IN-3

Catalog No. T22282Cas No. 2104030-82-0

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Pack Size	Price	Availability
1 mg	$76	In Stock
5 mg	$163	In Stock
10 mg	$289	In Stock
25 mg	$538	In Stock
50 mg	$778	In Stock
100 mg	$1,090	In Stock
1 mL x 10 mM (in DMSO)	$197	In Stock

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Product Introduction

Bioactivity

Description	Brr2-IN-3 (Brr2 Inhibitor C9) is an allosteric inhibitor of the spliceosomal RNA helicase Brr2. Brr2 is implicated in autosomal-dominant retinitis pigmentosa (a group of progressive retinal degenerative disorders).
Targets&IC50	BRR2:1.3 μM (IC50)
Alias	Brr2 Inhibitor 9, Brr2 Inhibitor C9

Chemical Properties

Molecular Weight	444.51
Formula	C₂₄H₂₀N₄O₃S
Cas No.	2104030-82-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 27.5 mg/mL (61.87 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2497 mL	11.2483 mL	22.4967 mL	112.4834 mL
5 mM	0.4499 mL	2.2497 mL	4.4993 mL	22.4967 mL
10 mM	0.2250 mL	1.1248 mL	2.2497 mL	11.2483 mL
20 mM	0.1125 mL	0.5624 mL	1.1248 mL	5.6242 mL
50 mM	0.0450 mL	0.2250 mL	0.4499 mL	2.2497 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

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Keywords

Inhibitorselectivedose-dependentBrr2IN3inhibitBrr2-IN-3helicaseBrr-2-IN-3targetingpotentallostericBrr2 IN 3