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Candoxatril
Candoxatril (UK 79300) is an orally active neutral peptide endonuclease (NEP, EC 3.4.24.11) inhibitor that improves exercise capacity in patients with chronic heart failure undergoing angiotensin-converting enzyme inhibition.
Catalog No. T10671Cas No. 123122-55-4
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Purity:99.56%
ee:99.14%
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Candoxatril
Catalog No. T10671Alias UK 79300Cas No. 123122-55-4
Candoxatril (UK 79300) is an orally active neutral peptide endonuclease (NEP, EC 3.4.24.11) inhibitor that improves exercise capacity in patients with chronic heart failure undergoing angiotensin-converting enzyme inhibition.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $293 | In Stock | |
| 5 mg | $719 | In Stock | |
| 10 mg | $987 | In Stock | |
| 25 mg | $1,490 | In Stock | |
| 50 mg | $1,980 | In Stock | |
| 100 mg | $2,750 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Candoxatril (UK 79300) is an orally active neutral peptide endonuclease (NEP, EC 3.4.24.11) inhibitor that improves exercise capacity in patients with chronic heart failure undergoing angiotensin-converting enzyme inhibition. |
| In vivo | NEP inhibitors do not significantly affect body weight, food and water intake, mean blood pressure, or creatinine levels; however, they increase cGMP levels in urine and exhibit anti-inflammatory effects on hematopoiesis. Additionally, a-SMA deposition in the kidney cortex is inversely correlated with cGMP elevation [2]. |
| Alias | UK 79300 |
| Molecular Weight | 515.64 |
| Formula | C29H41NO7 |
| Cas No. | 123122-55-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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