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Sacubitrilat

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Catalog No. TQ0106Cas No. 149709-44-4
Alias LBQ-657

Sacubitrilat (LBQ-657) (LBQ657) is an effective inhibitor of active neprilysin (NEP).

Sacubitrilat

Sacubitrilat

🥰Excellent
Purity: 99.17%
Catalog No. TQ0106Alias LBQ-657Cas No. 149709-44-4
Sacubitrilat (LBQ-657) (LBQ657) is an effective inhibitor of active neprilysin (NEP).
Pack SizePriceAvailabilityQuantity
1 mg$41In Stock
2 mg$57In Stock
5 mg$97In Stock
10 mg$163In Stock
25 mg$363In Stock
50 mg$578In Stock
100 mg$833In Stock
500 mg$1,690In Stock
1 mL x 10 mM (in DMSO)$97In Stock
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Purity:99.17%
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Product Introduction

Bioactivity
Description
Sacubitrilat (LBQ-657) (LBQ657) is an effective inhibitor of active neprilysin (NEP).
In vitro
Sacubitrilat is bound to the active site of NEP by an intricate network of interactions that involves all functional groups of the compound giving rise to the high inhibitory potency of 5?nM [1].
In vivo
Pharmacokinetics of Sacubitril, Sacubitrilat, and valsartan following the administration of single oral doses of LCZ696 400 or 1200 mg under fasting conditions are summarized. The mean plasma concentrations of Sacubitril increases rapidly with a median Tmax of 0.52 h for the 400 mg dose and 1.05 h for the 1200 mg dose, followed by Sacubitrilat, with the corresponding Tmax values of 2.07 and 3.05 h, respectively. The median Tmax for valsartan is 2.07 h for both the LCZ696 400 mg and 1200 mg doses. The Cmax of Sacubitrilat shows a dose-proportional increase, while the Cmax of Sacubitril and Valsartan shows less than proportional increases between the doses [2].
AliasLBQ-657
Chemical Properties
Molecular Weight383.44
FormulaC22H25NO5
Cas No.149709-44-4
SmilesC[C@H](C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)CCC(O)=O)C(O)=O
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (260.80 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6080 mL13.0398 mL26.0797 mL130.3985 mL
5 mM0.5216 mL2.6080 mL5.2159 mL26.0797 mL
10 mM0.2608 mL1.3040 mL2.6080 mL13.0398 mL
20 mM0.1304 mL0.6520 mL1.3040 mL6.5199 mL
50 mM0.0522 mL0.2608 mL0.5216 mL2.6080 mL
100 mM0.0261 mL0.1304 mL0.2608 mL1.3040 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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