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Centrinone-B
🥰Excellent
Catalog No. T14926Cas No. 1798871-31-4
Alias LCR-323, LCR323, LCR 323
Centrinone-B (LCR-323) is a potent and highly selective PLK4 inhibitor with a Ki of 0.59 nM.
Centrinone-B
🥰Excellent
Purity: 98.71%
Catalog No. T14926Alias LCR-323, LCR323, LCR 323Cas No. 1798871-31-4
Centrinone-B (LCR-323) is a potent and highly selective PLK4 inhibitor with a Ki of 0.59 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $199 | In Stock |
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Purity:98.71%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Centrinone-B (LCR-323) is a potent and highly selective PLK4 inhibitor with a Ki of 0.59 nM. |
| Targets&IC50 | PLK4 (G95L):497.53 nM (Ki), Aurora A:1239 nM (Ki), Aurora B:5597.14 nM (Ki), PLK4:0.59 nM (Ki) |
| In vitro | Centrinone-B (LCR-323) is a highly potent and selective PLK4 inhibitor that can reduce centrosomes without affecting Aurora A/B, and it induces apoptosis in most melanoma cell lines[2]. |
| Alias | LCR-323, LCR323, LCR 323 |
| Molecular Weight | 631.67 |
| Formula | C27H27F2N7O5S2 |
| Cas No. | 1798871-31-4 |
| Smiles | COc1c(Nc2cc(C)[nH]n2)nc(Sc2ccc(cc2F)S(=O)(=O)Cc2cccc(c2F)[N+]([O-])=O)nc1N1CCCCC1 |
| Relative Density. | 1.54 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (31.66 mM), Sonication is recommended. H2O: < 0.1 mg/mL (insoluble) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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