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Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 mg | $33 | In Stock | |
100 mg | $47 | In Stock | |
200 mg | $68 | In Stock | |
500 mg | $112 | In Stock | |
1 mL x 10 mM (in DMSO) | $52 | In Stock |
Description | Citiolone (Thioxidrene) is a thiolic-derived medication as a mucolytic agent for the treatment of certain hepatic disorders. |
In vitro | OSI-027 shows the selective and ATP competitive inhibition activities against mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively. In addition, OSI-027 inhibits mTOR signaling of phospho-4E-BP1 with an IC50 of 1 μM in cell-based assays. [1] OSI-027 exhibits anti-proliferative activities against several acute leukemia cell lines of myeloid/megakaryocytic origin in a dose-dependent manner, including U937, KG-1, KBM-3B, ML-1, HL-60, and MEG-01 cells. [2] A recent study shows that inhibition of mTORC1/2 by OSI-027 effectively suppresses phosphorylation of Akt (S473) and cell proliferation in breast cancer cells. [3] |
Alias | Thioxidrene, Citiolase |
Molecular Weight | 159.21 |
Formula | C6H9NO2S |
Cas No. | 1195-16-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 29 mg/mL (182.1 mM) DMSO: 65 mg/mL (408.27 mM) ![]() H2O: 29 mg/mL (182.1 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
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