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Clamikalant sodium
🥰Excellent
Catalog No. T63330Cas No. 261717-22-0
Alias HMR1098, HMR 1098
Clamikalant sodium (HMR 1098) is an ATP-dependent potassium channel (KATP) cardiac-selective blocker, used in the study of arrhythmias.
Clamikalant sodium
🥰Excellent
Catalog No. T63330Alias HMR1098, HMR 1098Cas No. 261717-22-0
Clamikalant sodium (HMR 1098) is an ATP-dependent potassium channel (KATP) cardiac-selective blocker, used in the study of arrhythmias.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $64 | In Stock | |
| 5 mg | $153 | In Stock | |
| 10 mg | $282 | In Stock | |
| 25 mg | $628 | In Stock | |
| 50 mg | $818 | In Stock | |
| 100 mg | $1,280 | In Stock | |
| 200 mg | $1,760 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $173 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Clamikalant sodium (HMR 1098) is an ATP-dependent potassium channel (KATP) cardiac-selective blocker, used in the study of arrhythmias. |
| Targets&IC50 | sK (ATP):0.36 mM |
| In vitro | Clamikalant sodium is a selective sarcosine K (ATP) channel inhibitor. It blocks the sK (ATP) current (IC (50) =0.36 mM) induced by the K (ATP) opener pinacidil. [1] In mouse atrial myocytes, both spontaneous activation and diazine-activated K (ATP) currents were effectively inhibited by 10 μM Clamikalant sodium. In contrast, in ventricular myocytes, high concentrations of Clamikalant sodium (100 μM) inhibited the K (ATP) current activated by the pinate, but low concentrations (10 μM) did not. Consistent with this finding, in COSm6 cells, Clamikalant sodium inhibits (86) Rb (+) efflux through Kir6.2/SUR1 more effectively than the Kir6.2/SUR2A channel. [2] |
| In vivo | Clamikalant sodium treatment (3 mg/kg push followed by continuous intravenous injection at 17 μg/kg/min throughout the study) did not prevent the shortening of HRA-ERP and the flattening or inversion of ERP rate adaptation in dogs. [3] |
| Alias | HMR1098, HMR 1098 |
| Molecular Weight | 493.96 |
| Formula | C19H21ClN3NaO5S2 |
| Cas No. | 261717-22-0 |
| Smiles | O=C(C1=CC(Cl)=CC=C1OC)NCCC2=CC=C(C(S(=O)([N-]C(NC)=S)=O)=C2)OC.[Na+] |
Storage & Solubility Information
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40.00 mg/mL (80.98 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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