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Cu(II)GTSM
🥰Excellent
Catalog No. T40792Cas No. 68341-14-0
Alias Cu-GTSM
Cu(II)GTSM is a cell permeable copper complex that significantly inhibits GSK3β activity and suppresses levels of neurotoxic amyloid β-trimers and phosphorylated tau, and is able to reverse cognitive deficits in Alzheimer's disease mice.
Cu(II)GTSM
🥰Excellent
Catalog No. T40792Alias Cu-GTSMCas No. 68341-14-0
Cu(II)GTSM is a cell permeable copper complex that significantly inhibits GSK3β activity and suppresses levels of neurotoxic amyloid β-trimers and phosphorylated tau, and is able to reverse cognitive deficits in Alzheimer's disease mice.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $40 | In Stock | |
| 5 mg | $70 | In Stock | |
| 10 mg | $120 | In Stock | |
| 25 mg | $270 | In Stock | |
| 50 mg | $460 | In Stock | |
| 100 mg | $780 | In Stock | |
| 200 mg | $1,170 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $73 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Cu(II)GTSM is a cell permeable copper complex that significantly inhibits GSK3β activity and suppresses levels of neurotoxic amyloid β-trimers and phosphorylated tau, and is able to reverse cognitive deficits in Alzheimer's disease mice. |
| In vitro | Methods: PC12 cells treated with NGF for 48 hours were treated with Cu(II)GTSM (25, 50, 100 nM, 18 hours) and then examined. Results: MTT assay Results showed a small but significant loss of MTT reduction at 25 and 50 nMd of Cu(II)GTSM treatment; LDH assay showed that there was actually a small but significant reduction in LDH release when using 100 nM Cu(II)GTSM. [3] |
| In vivo | Treatment of AD mice with Cu(II)GTSM (10 mg/kg) can reduce the level of brain Aβ trimers in AD mice, restore the cognitive ability of AD mice to the expected level of healthy, cognitively normal mice, and reverse the cognitive deficits of APP/PS1 transgenic AD mice. [2] |
| Alias | Cu-GTSM |
| Molecular Weight | 293.86 |
| Formula | C6H10CuN6S2 |
| Cas No. | 68341-14-0 |
| Smiles | N1=C([S-][Cu+2]23[S-]C(=N[N]3=CC=[N]12)NC)NC |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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