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D-NMAPPD
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Catalog No. T22069Cas No. 35922-06-6
Alias (1R,2R)-B13
D-NMAPPD ((1R,2R)-B13) is an acid ceramidase inhibitor and ceramide analog with potential antiproliferative activity that modulates ceramide signaling in human melanoma cells. D-NMAPPD is used in the study of colon cancer.
D-NMAPPD
😃Good
Catalog No. T22069Alias (1R,2R)-B13Cas No. 35922-06-6
D-NMAPPD ((1R,2R)-B13) is an acid ceramidase inhibitor and ceramide analog with potential antiproliferative activity that modulates ceramide signaling in human melanoma cells. D-NMAPPD is used in the study of colon cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $73 | 35 days | |
| 5 mg | $268 | 35 days | |
| 10 mg | $493 | 35 days | |
| 50 mg | $1,930 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | D-NMAPPD ((1R,2R)-B13) is an acid ceramidase inhibitor and ceramide analog with potential antiproliferative activity that modulates ceramide signaling in human melanoma cells. D-NMAPPD is used in the study of colon cancer. |
| In vitro | In rat hippocampal slices, NMDA receptor-mediated field excitatory postsynaptic potentials (fEPSPs) at synapses in the CA1 region were significantly enhanced by pretreatment with the acidic ceramidase inhibitor D-NMAPPD. [1] |
| Alias | (1R,2R)-B13 |
| Molecular Weight | 422.56 |
| Formula | C23H38N2O5 |
| Cas No. | 35922-06-6 |
| Smiles | [C@@H]([C@H](NC(CCCCCCCCCCCCC)=O)CO)(O)C1=CC=C(N(=O)=O)C=C1 |
| Relative Density. | 1.101 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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