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Deferitazole

🥰Excellent
Catalog No. T31362Cas No. 945635-15-4
Alias SPD-602, SPD602, SPD 602, FBS-0701, FBS0701, FBS 0701

Deferitazole (FBS 0701) is a novel and orally active, selective and high affinity iron chelator.

Deferitazole

Deferitazole

🥰Excellent
Purity: 98.26%
Catalog No. T31362Alias SPD-602, SPD602, SPD 602, FBS-0701, FBS0701, FBS 0701Cas No. 945635-15-4
Deferitazole (FBS 0701) is a novel and orally active, selective and high affinity iron chelator.
Pack SizePriceAvailabilityQuantity
1 mg$130In Stock
5 mg$320In Stock
10 mg$480In Stock
25 mg$786In Stock
50 mg$1,080In Stock
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Purity:98.26%
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Product Introduction

Bioactivity
Description
Deferitazole (FBS 0701) is a novel and orally active, selective and high affinity iron chelator.
In vitro
Deferitazole (FBS0701) displays a high affinity and selectivity for iron(III) as demonstrated by the log β2 = 33.39 ± 0.03 and the pFe(3+) value of 22.3. Two equilibrating isomeric forms of the iron(III) complex exist under biological conditions. Deferitazole also binds the trivalent metals Al(III) and La(III) with high affinity; log β2 values, 26.68 and 21.55 respectively. The affinity of Deferitazole for divalent cations is somewhat lower, with the exception of Cu(II) which possesses a log β2 value of 25.5; Deferitazole scavenges iron from labile sources such as citrate and albumin with efficiencies comparable with those of other therapeutic iron chelators, including deferasirox, deferiprone and desferrioxamine. The Fe(III)(Deferitazole)2 is stable under physiological conditions and does not redox cycle. The high affinity of Deferitazole for iron(III) renders it unlikely that this chelator will lead to the redistribution of iron and consequently Deferitazole shows considerable promise as a therapeutic iron(III) chelator.[1]
AliasSPD-602, SPD602, SPD 602, FBS-0701, FBS0701, FBS 0701
Chemical Properties
Molecular Weight399.46
FormulaC18H25NO7S
Cas No.945635-15-4
SmilesOC1=C(C2=N[C@](C(O)=O)(C)CS2)C=CC=C1OCCOCCOCCOC
Relative Density.1.30 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (125.17 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5034 mL12.5169 mL25.0338 mL125.1690 mL
5 mM0.5007 mL2.5034 mL5.0068 mL25.0338 mL
10 mM0.2503 mL1.2517 mL2.5034 mL12.5169 mL
20 mM0.1252 mL0.6258 mL1.2517 mL6.2584 mL
50 mM0.0501 mL0.2503 mL0.5007 mL2.5034 mL
100 mM0.0250 mL0.1252 mL0.2503 mL1.2517 mL

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