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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $168 | In Stock | |
2 mg | $265 | In Stock | |
5 mg | $502 | In Stock | |
10 mg | $678 | In Stock | |
25 mg | $1,425 | In Stock | |
50 mg | $2,350 | In Stock | |
100 mg | $3,560 | In Stock |
Description | diABZI STING agonist-1 (Tautomerism) (diABZI STING agonist (Compound 3)) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. |
In vitro | diABZI STING agonist-1 (Tautomerism) is a selective stimulator of interferon gene (STING) receptor agonists, with EC50 of 130 and 186 nM for humans and mice, respectively. diABZI STING agonist-1 (Tautomerism) at a concentration of 1 μM showed high selectivity for more than 350 kinases tested[1]. |
In vivo | diABZI STING agonist-1 (Tautomerism)(subcutaneous injection; 2.5 mg/kg) induces STING-dependent activation of type I interferon and proinflammatory cytokines in vivo. diABZI STING agonist-1 (Tautomerism) (intravenous; 3 mg/kg) exhibited systemic exposure with a half-life of 1.4 hours and reached a systemic concentration greater than half the maximum effective concentration of STING in mice (EC50) 200 ng/kg) ml). diABZI STING agonist-1 (Tautomerism) (intravenous; 1.5 mg / kg; 43 days) can significantly inhibit tumor growth and significantly improve survival rate (P <0.001). Eight out of 10 mice are tumor-free[1]. |
Alias | diABZI STING agonist (Compound 3) |
Molecular Weight | 849.94 |
Formula | C42H51N13O7 |
Cas No. | 2138498-18-5 |
Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years |
Solubility Information | DMSO: < 1 mg/mL (insoluble), Sonication is recommended. ![]() |
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