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EGFR-IN-61

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Catalog No. T73128Cas No. 2890261-81-9

EGFR-IN-61 (compound 22a), a potent EGFR kinase inhibitor, exhibits IC50 values of 42 nM for L858R/T790M, 137 nM for L858R/T790M/C797S, and 743 nM for WT. Additionally, it demonstrates antiproliferative activity against the A549 and H1975 cell lines, with IC50 values of 2.14 μM and 1.82 μM, respectively [1].

EGFR-IN-61

EGFR-IN-61

😃Good
Catalog No. T73128Cas No. 2890261-81-9
EGFR-IN-61 (compound 22a), a potent EGFR kinase inhibitor, exhibits IC50 values of 42 nM for L858R/T790M, 137 nM for L858R/T790M/C797S, and 743 nM for WT. Additionally, it demonstrates antiproliferative activity against the A549 and H1975 cell lines, with IC50 values of 2.14 μM and 1.82 μM, respectively [1].
Pack SizePriceAvailabilityQuantity
25 mg$1,5208-10 weeks
50 mg$1,9808-10 weeks
100 mg$2,5008-10 weeks
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Product Introduction

Bioactivity
Description
EGFR-IN-61 (compound 22a), a potent EGFR kinase inhibitor, exhibits IC50 values of 42 nM for L858R/T790M, 137 nM for L858R/T790M/C797S, and 743 nM for WT. Additionally, it demonstrates antiproliferative activity against the A549 and H1975 cell lines, with IC50 values of 2.14 μM and 1.82 μM, respectively [1].
Targets&IC50
EGFR (WT):743 ± 20 nM, EGFR (L858R/T790M):42 ± 2 nM, EGFR L858R/T790M/C797S:137 ± 6 nM
In vitro
EGFR-IN-61 (compound 22a) demonstrates superior selectivity for the L858R/T790M/C797S EGFR kinase mutant over the wild type, with a selectivity ratio of 5.4 [1].
Chemical Properties
Molecular Weight629.15
FormulaC33H37ClN8O3
Cas No.2890261-81-9
Storage & Solubility Information
StorageShipping with blue ice.

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