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Ensaculin

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Purity:99.27%

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COA HNMR HPLC LCMS

Ensaculin

Catalog No. T67955Cas No. 155773-59-4

Ensaculin (Anseculin), a novel benzopyrone partially substituted with piperazine, showed memory-enhancing effects in passive and conditioned avoidance paradigms in normal and artificially amnesic rodents. It showed neuroprotective activity in a model of NMDA toxicity and neurotrophic effects in primary cultured rat brain cells.Ensaculin can be used for the treatment of dementia.

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Pack Size	Price	Availability
1 mg	$128	In Stock
5 mg	$320	In Stock
10 mg	$470	In Stock
25 mg	$772	In Stock
50 mg	$1,080	In Stock
100 mg	$1,460	In Stock
500 mg	$2,920	In Stock

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Product Introduction

Bioactivity

Description	Ensaculin (Anseculin), a novel benzopyrone partially substituted with piperazine, showed memory-enhancing effects in passive and conditioned avoidance paradigms in normal and artificially amnesic rodents. It showed neuroprotective activity in a model of NMDA toxicity and neurotrophic effects in primary cultured rat brain cells.Ensaculin can be used for the treatment of dementia.
In vivo	Ensaculin (0.1, 1 and 10 mg/kg; i.p.; Wistar rats; 20 min after the onset of glutamate perfusion) significantly antagonized the formation of 2,3-DHBA, to values of 60.5% and 56.7% of control levels, respectively. Ensaculin may be useful in the treatment of neurodegenerative disorders associated with elevated hydroxyl free radicals and excitotoxicity.[1]
Alias	Anseculin

Chemical Properties

Molecular Weight	452.54
Formula	C26H32N2O5
Cas No.	155773-59-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 42.6 mg/mL (94.03 mM )

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2097 mL	11.0487 mL	22.0975 mL	110.4875 mL
5 mM	0.4419 mL	2.2097 mL	4.4195 mL	22.0975 mL
10 mM	0.2210 mL	1.1049 mL	2.2097 mL	11.0487 mL
20 mM	0.1105 mL	0.5524 mL	1.1049 mL	5.5244 mL
50 mM	0.0442 mL	0.2210 mL	0.4419 mL	2.2097 mL

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In Vivo Formulation Calculator (Clear solution)

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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