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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $34 | In Stock | |
5 mg | $55 | In Stock | |
10 mg | $97 | In Stock | |
25 mg | $197 | In Stock | |
50 mg | $328 | In Stock | |
100 mg | $497 | In Stock | |
200 mg | $693 | In Stock | |
500 mg | $1,080 | In Stock |
Description | ERCC1-XPF-IN-2 is active in nucleotide excision repair, cisplatin enhancement and γH2AX assays. ERCC1-XPF-IN-2 is a potent inhibitor of ERCC1-XPF endonuclease with an IC 50 value of 0.6 μM [1]. |
In vitro | ERCC1-XPF-IN-2 (compound 13) (0-100 µM) shows DNase I and FEN-1 activity with IC50s of >100, >100 µM, respectively. ERCC1-XPF-IN-2 shows binding kinetics with Kd of ~30 µM. ERCC1-XPF-IN-2 has nontoxic to Hep-G2 cells at 10 µM and relatively short mouse and human microsomal half-lives with t1/2 of 23 min and 28 min for mouse and human, respectively. ERCC1-XPF-IN-2 (0-60 µM; 24 h) shows inhibition of nucleotide excision repair (NER) with an IC50 of 15.6 μM in A375 cells. ERCC1-XPF-IN-2 (0-60 µM) increases the cisplatin activity with nontoxic. ERCC1-XPF-IN-2 (10 µM; 6h) causes a delay in DNA repair by a right shift towards higher numbers of γH2AX foci per cell[1]. |
Molecular Weight | 326.17 |
Formula | C15H13Cl2NO3 |
Cas No. | 1808986-37-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 225.0 mg/mL (689.8 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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