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Farletuzumab
Catalog No. T76720Cas No. 896723-44-7
Alias MORAb-003
Farletuzumab (MORAb-003) is a humanized monoclonal antibody with a high affinity for folate receptor-α (FRα), acting as a potent inhibitor of FRα and impeding the growth of cells that overexpress this receptor, making it useful for cancer research.
Farletuzumab
Farletuzumab
Catalog No. T76720Alias MORAb-003Cas No. 896723-44-7
Farletuzumab (MORAb-003) is a humanized monoclonal antibody with a high affinity for folate receptor-α (FRα), acting as a potent inhibitor of FRα and impeding the growth of cells that overexpress this receptor, making it useful for cancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $372 | In Stock | |
| 5 mg | $933 | In Stock | |
| 10 mg | $1,490 | In Stock | |
| 25 mg | $2,190 | In Stock | |
| 50 mg | $2,970 | In Stock | |
| 100 mg | $3,930 | In Stock |
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View MoreInhibitors Related to "Farletuzumab"
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Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Organic Cation Transporter 2 Inhibitor.
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Pemetrexed
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Methotrexate
Cited
WR19039, NCI-C04671, CL14377, Amethopterin
T148559-05-2
Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and various tumors.
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CitedTrimethoprim lactate
Primsol lactate, NSC-106568 lactate, NIH204 lactate, NIH 204 lactate, BW56-72 lactate, BW 56-72 lactate
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Folinic acid calcium
Wellcovorin, Leucovorin Calcium, Folinic acid calcium salt, Calcium folinate
T01481492-18-8
Folinic acid calcium (Leucovorin Calcium) is the active metabolite of folic acid. Leucovorin is used principally as an antidote to folic acid antagonists.
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Folinic acid
Leucovorin, HSDB 6544
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Folinic acid (Leucovorin) is a biofolate used in the treatment of methotrexate (MTX) toxicity reduction and as an adjuvant therapy for colon cancer.
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Pemetrexed disodium
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Diaveridine
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Folinic Acid Calcium Salt Pentahydrate
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Folinic Acid Calcium Salt Pentahydrate (Leucovorin Calcium Pentahydrate), a reduced folic acid, is used in combination with other chemotherapeutics.
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Levomefolate calcium
T7593151533-22-1
Levomefolate calcium, an artificial form of folate, is a coenzymated form of folic acid that offers a more bioavailable alternative in dietary supplements.
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Levoleucovorin Calcium
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Pyrimethamine
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Concentration:19.19 mg/mL
Purity:> 95%
Contact us for more batch information
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Product Introduction
Bioactivity
Chemical Properties
| Description | Farletuzumab (MORAb-003) is a humanized monoclonal antibody with a high affinity for folate receptor-α (FRα), acting as a potent inhibitor of FRα and impeding the growth of cells that overexpress this receptor, making it useful for cancer research. |
| In vitro | In CHO-FR cells, Farletuzumab (MORAb-003; 0-10 µg/mL) inhibits FRα-dependent cell growth and increases folate EC50 in a dose-dependent manner[1]. In IGROV-1 cells (0.1-100 µg/mL; 1 h), Farletuzumab mediates tumor cytotoxicity in vitro through complement-dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC)[1]. In CHO-FR cells (0-10 µg/mL), Farletuzumab inhibits the phosphorylation of proteins by Lyn kinase, a member of the src family of kinases, thereby blocking an FRα-mediated signaling pathway[1]. |
| Alias | MORAb-003 |
| Molecular Weight | 145.36 kDa |
| Cas No. | 896723-44-7 |
Storage & Solubility Information
| Storage | store at low temperature | store at -80°C | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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