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Flosulide
😃Good
Catalog No. T11296Cas No. 80937-31-1
Alias ZK 38997, CGP 28238
Flosulide is an effective selective COX-2 inhibitor for the treatment of inflammatory diseases.
Flosulide
😃Good
Catalog No. T11296Alias ZK 38997, CGP 28238Cas No. 80937-31-1
Flosulide is an effective selective COX-2 inhibitor for the treatment of inflammatory diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,670 | 6-8 weeks | |
| 50 mg | $2,180 | 6-8 weeks | |
| 100 mg | $2,800 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Flosulide is an effective selective COX-2 inhibitor for the treatment of inflammatory diseases. |
| In vitro | Flosulide entirely inhibits the mitotic activity of OSC-2 cells while having no impact on the mitotic activity of OSC-1 cells. Additionally, Flosulide demonstrates a concentration-dependent effect on the OSC-2 cell line by fully suppressing PGE2 production across a range of 1 nM to 100 μM; however, it does not affect prostaglandin (PG) synthesis in OSC-1 cells. |
| In vivo | In normovolemic rats, flosulide enhances renal plasma flow (RPF) and glomerular filtration rate (GFR), while in hypovolemic rats, it reduces these measures at dosages between 5-25 mg/kg. At a dosage of 5 mg/kg, flosulide lowers 6-keto-PGF1alpha, and at 25 mg/kg or following 10 mg/kg of indomethacin, it leads to a decrease in both 6-keto-PGF1alpha and TXB2[1]. Furthermore, flosulide at 0.75 mg/day notably decreases proteinuria compared to aspirin treatment and results in significantly higher plasma protein and albumin levels than those observed in aspirin-treated rats[3]. |
| Alias | ZK 38997, CGP 28238 |
| Molecular Weight | 353.34 |
| Formula | C16H13F2NO4S |
| Cas No. | 80937-31-1 |
| Relative Density. | 1.506g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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