store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
FPFT-2216 is a "molecular glue" compound that degrades IKZF6, IKZF1, DE1D, and CK3α. FPFT-2216 has potential antitumor activity and can be used to study immune system diseases.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 5 days | $ 954.00 | |
50 mg | 5 days | $ 1,240.00 | |
100 mg | 5 days | $ 1,990.00 |
Description | FPFT-2216 is a "molecular glue" compound that degrades IKZF6, IKZF1, DE1D, and CK3α. FPFT-2216 has potential antitumor activity and can be used to study immune system diseases. |
In vitro |
FPFT-2216 (1 μM; 5 hours) not only degrades its known targets IKZF1, IKZF3, and CK1α in MOLT4 cells but also demonstrates the degradation of PDE6D[2]. FPFT-2216 (1 μM; 0 h, 2 h, 4 h, 6 h, 16 h, 24 h) shows complete degradation of PDE6D within 2 hours, and the degradation of PDE6D persists for at least 24 hours in MOLT4 cells[1].FPFT-2216 (0 nM, 1.6 nM, 8 nM, 40 nM, 200 nM, 1 μM; 4 hours) exhibits over 50% degradation of PDE6D at the dose of 8 nM, with maximal degradation of PDE6D, IKZF1, IKZF3, and CK1α observed at the dose of 200 nM in MOLT4 cells[2]. FPFT-2216 does not impede the growth of KRASG12C-dependent MIA PaCa-2 cells[1].FPFT-2216 (10, 20, 40 μM; 14 or 24 hours) significantly upregulates IL-2, although its effect in naive CD4+ T cells is less potent than Pomalidomide[2].FPFT-2216 (10 μM; 14 or 24 hours) degrades the immune modulatory drug (IMiD) ubiquitin-proteasome degradation substrates IKZF1 and CK-1α in naive CD4+ T cells[1]. |
In vivo | FPFT-2216 (30 mg/kg; oral or intraperitoneal) induces significant degradation of CK-1α and IKZF1 in CRBNI391V mice[1]. |
Molecular Weight | 292.31 |
Formula | C12H12N4O3S |
CAS No. | 2367619-87-0 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 20 mg/mL (68.42 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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FPFT-2216 2367619-87-0 Metabolism PROTAC Stem Cells Casein Kinase PDE Molecular Glues inhibitor inhibit