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FSC231
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Catalog No. T86471Cas No. 1215849-96-9
FSC231 is a PSD-95/DLG/ZO-1 (PDZ) domain inhibitor of PICK1 with analgesic effects [1].
FSC231
😃Good
Catalog No. T86471Cas No. 1215849-96-9
FSC231 is a PSD-95/DLG/ZO-1 (PDZ) domain inhibitor of PICK1 with analgesic effects [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | FSC231 is a PSD-95/DLG/ZO-1 (PDZ) domain inhibitor of PICK1 with analgesic effects [1]. |
| In vitro | FSC231 (50 μM) inhibits the interaction between GluR2 and PICK1 in COS7 cells [2]. |
| In vivo | FSC231 (total 78.40 μg/kg daily, administered via intraperitoneal injection seven times, completed 3 hours before paclitaxel treatment) alleviates paclitaxel-induced neuralgia in rats [1]. Additionally, FSC231 (39.2 μg/kg/day, intraperitoneally, for 4 weeks) inhibits the development of diabetic cardiomyopathy in rats by partially suppressing ROS production and apoptosis through the PICK1/eNOS/cGMP pathway [3]. Animal Model: Paclitaxel-induced neuralgia in rats [1] Dosage: 78.40 μg/kg total Administration: i.p., daily, seven times, 3 hours prior to Paclitaxel Result: Mitigated changes in inflammatory cytokines (IL-6, TNF-α, and IL-10) and inhibited the phosphorylation of GSK-3β and ERK1/2. |
| Molecular Weight | 313.14 |
| Formula | C13H10Cl2N2O3 |
| Cas No. | 1215849-96-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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