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Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 mg | $29 | In Stock |
Description | Gamma-Methylleucine (2-Amino-3-tert-butylpropionic acid) is an auxiliary for copper-catalyzed asymmetric Michael reactions. |
In vivo | gamma-Methylleucine improved the binding affinity of the peptide for Y2R but also increased its anorectic activity in lean mice [1]. Gamma-methylleucine resulted in loss of or significantly decreased the biological activity of ET-1, while high affinity for the ETA (IC50 = 0.42-0.70 nM) and ETB (IC50 = 0.17-0.43 nM) receptor was retained [2]. Gamma-methylleucine was shown to have high antagonist activitiesin Sarafotoxin S6c-induced vasoconstriction of rabbit pulmonary artery (ET-1: pA2 8.4) and have the desirable characteristic of possessing no agonist activity at either receptor subtype [2]. |
Alias | L-Neopentylglycine, gamma-Methyl-L-leucine, 2-Amino-3-tert-butylpropionic acid |
Molecular Weight | 145.2 |
Formula | C7H15NO2 |
Cas No. | 57224-50-7 |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: < 1.45 mg/mL (10 mM, insoluble or slightly soluble) ![]() | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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