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Gamma-Methylleucine

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COA HNMR

Gamma-Methylleucine

Catalog No. T31907Cas No. 57224-50-7

Gamma-Methylleucine (2-Amino-3-tert-butylpropionic acid) is an auxiliary for copper-catalyzed asymmetric Michael reactions.

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Pack Size	Price	Availability	Quantity
100 mg	$29	In Stock

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Product Introduction

Bioactivity

Description	Gamma-Methylleucine (2-Amino-3-tert-butylpropionic acid) is an auxiliary for copper-catalyzed asymmetric Michael reactions.
In vivo	gamma-Methylleucine improved the binding affinity of the peptide for Y2R but also increased its anorectic activity in lean mice [1]. Gamma-methylleucine resulted in loss of or significantly decreased the biological activity of ET-1, while high affinity for the ETA (IC50 = 0.42-0.70 nM) and ETB (IC50 = 0.17-0.43 nM) receptor was retained [2]. Gamma-methylleucine was shown to have high antagonist activitiesin Sarafotoxin S6c-induced vasoconstriction of rabbit pulmonary artery (ET-1: pA2 8.4) and have the desirable characteristic of possessing no agonist activity at either receptor subtype [2].
Alias	L-Neopentylglycine, gamma-Methyl-L-leucine, 2-Amino-3-tert-butylpropionic acid

Chemical Properties

Molecular Weight	145.2
Formula	C7H15NO2
Cas No.	57224-50-7

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: < 1.45 mg/mL (10 mM, insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.8871 mL	34.4353 mL	68.8705 mL	344.3526 mL
5 mM	1.3774 mL	6.8871 mL	13.7741 mL	68.8705 mL
10 mM	0.6887 mL	3.4435 mL	6.8871 mL	34.4353 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Gamma-MethylleucineGammaMethylleucineinhibitInhibitorGamma Methylleucine