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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $148 | In Stock | |
5 mg | $372 | In Stock | |
10 mg | $556 | In Stock | |
25 mg | $896 | In Stock | |
50 mg | $1,220 | In Stock | |
100 mg | $1,650 | In Stock | |
1 mL x 10 mM (in DMSO) | $397 | In Stock |
Description | GKI-1 is a Greatwall (GWL) kinase inhibitor that inhibits hGWLFL with an IC50 of 4.9. GKI-1 also inhibited hGWL-KinDom, and its IC50 was 2.5 µM. The inhibitory effect of GKI-1 on ROCK1 was better than that of hGWLFL and hGWL-KinDom, and its IC50 was 11 µM, which only weakly inhibited PKA. |
In vitro | Treatment of HeLa cells with GKI-1 (25 and 50µM, 0-8.5 h) reduced ENSA/ARPP19 phosphorylation levels, resulting in reduced mitotic events, mitotic arrest/cell death, and cell division failure. GKI-1 inhibited full-length human GWL and showed cellular effects[1] |
Molecular Weight | 269.73 |
Formula | C15H12ClN3 |
Cas No. | 2444764-03-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 180.0 mg/mL (667.3 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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