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Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | $41 | In Stock | |
25 mg | $61 | In Stock | |
50 mg | $82 | In Stock | |
100 mg | $141 | In Stock | |
1 mL x 10 mM (in DMSO) | $45 | In Stock |
Description | GMQ hydrochloride (NSC-403387 hydrochloride) is a potent and selective acid-sensing ion channel (ASIC) modulator. It activates ASIC3 channels under neutral pH and blocks acid-induced maximal peak current. |
In vitro | Addition of GMQ to pituitary GH3 cells raised the amplitude of Ca2+-activated K+ currents (IK(Ca)), which was reversed by verruculogen or PF1022A, but not by TRAM-39.?Under inside-out current recordings, addition of GMQ into bath enhanced the probability of large-conductance Ca2+-activated K+ (BKCa) channels with an EC50 value of 0.95 M. The activation curve of BKCa channels during exposure to GMQ shifted to a lower depolarized potential, with no change in the gating charge of the curve;?however, there was a reduction of free energy for channel activation in its presence.?As cells were exposed to GMQ, the amplitude of ion currents were suppressed, including delayed rectifying K+ current, voltage-gated Na+ and L-type Ca2+ currents.?In Rolf B1.T olfactory sensory neuron, addition of GMQ was able to induce inward current and to suppress peak INa. |
Alias | NSC 403387 hydrochloride |
Molecular Weight | 237.69 |
Formula | C10H12ClN5 |
Cas No. | 5361-15-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||
Solubility Information | DMSO: 2.38 mg/mL (10 mM) ![]() | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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