GPR84 antagonist 8

GPR84 antagonist 8 is a selective GPR84 antagonist.

Catalog No. T11462Cas No. 1445846-30-9

Resource Download

GPR84 antagonist 8

Catalog No. T11462Cas No. 1445846-30-9

GPR84 antagonist 8 is a selective GPR84 antagonist.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
25 mg	$4,528	6-8 weeks
50 mg	$6,339	6-8 weeks
100 mg	$8,879	6-8 weeks

Bulk & Custom

Add to Cart

Questions

Product Introduction

Bioactivity

Description

GPR84 antagonist 8 is a selective GPR84 antagonist.

In vitro

GPR84 antagonist 8 is shown to effectively counteract the decrease in cAMP production triggered by 6-OAU in GPR84-CHO cells, hinting at its ability to inhibit GPR84's action. To examine its potential in mitigating GPR84 activation's pro-inflammatory effects in macrophages, bone marrow-derived macrophages (BMDMs) pretreated with LPS were exposed to 10μM of the antagonist for 30 minutes prior to the introduction of 1μM 6-OAU. Western Blot analysis indicated that GPR84 antagonist 8 notably reduces the phosphorylation of AKT and ERK prompted by 6-OAU, showcasing its partial blockade. Given GPR84's prominence in immune cells as part of the G protein-coupled receptor family associated with metabolism, utilizing GPR84 antagonist 8 emerges as a promising anti-inflammatory approach against various inflammatory diseases. The antagonist's effectiveness and specificity were further validated through cAMP assay trials conducted on GPR84-CHO cells.

Chemical Properties

Molecular Weight	421.45
Formula	C₂₃H₂₃N₃O₅
Cas No.	1445846-30-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 5 mg/mL (11.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3728 mL	11.8638 mL	23.7276 mL	118.6380 mL
5 mM	0.4746 mL	2.3728 mL	4.7455 mL	23.7276 mL
10 mM	0.2373 mL	1.1864 mL	2.3728 mL	11.8638 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc