Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

GSK 690 Hydrochloride

😃Good
Catalog No. T11503Cas No. 2436760-79-9

GSK 690 (Hydrochloride) is a reversible lysine-specific demethylase 1 (LSD1) inhibitor with a Kd of 9 nM and an IC50 of 37 nM.

GSK 690 Hydrochloride

GSK 690 Hydrochloride

😃Good
Catalog No. T11503Cas No. 2436760-79-9
GSK 690 (Hydrochloride) is a reversible lysine-specific demethylase 1 (LSD1) inhibitor with a Kd of 9 nM and an IC50 of 37 nM.
Pack SizePriceAvailabilityQuantity
100 mg$1,4501-2 weeks
200 mg$1,9361-2 weeks
Bulk & Custom
Add to Cart
Questions
View More
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
GSK 690 (Hydrochloride) is a reversible lysine-specific demethylase 1 (LSD1) inhibitor with a Kd of 9 nM and an IC50 of 37 nM.
Targets&IC50
LSD1:(kd)8 nM , LSD1:37 nM
In vitro
GSK690 (1-10 μM) synergizes with JNJ-26481585 to promote cell death across four RMS cell lines (RD, RH30, RMS13, and TE381.T cells), impacting the equilibrium of pro- and antiapoptotic proteins at 1 μM for RD cells and at 10 μM for RH30 cells. This combined treatment triggers caspase-dependent apoptosis at these same concentrations for RD and RH30 cells, respectively, and amplifies JNJ-26481585-induced G2/M phase arrest.
Chemical Properties
Molecular Weight405.92
FormulaC24H24ClN3O
Cas No.2436760-79-9
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 125 mg/mL (307.94 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4635 mL12.3177 mL24.6354 mL123.1770 mL
5 mM0.4927 mL2.4635 mL4.9271 mL24.6354 mL
10 mM0.2464 mL1.2318 mL2.4635 mL12.3177 mL
20 mM0.1232 mL0.6159 mL1.2318 mL6.1588 mL
50 mM0.0493 mL0.2464 mL0.4927 mL2.4635 mL
100 mM0.0246 mL0.1232 mL0.2464 mL1.2318 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy GSK 690 Hydrochloride | purchase GSK 690 Hydrochloride | GSK 690 Hydrochloride cost | order GSK 690 Hydrochloride | GSK 690 Hydrochloride chemical structure | GSK 690 Hydrochloride in vitro | GSK 690 Hydrochloride formula | GSK 690 Hydrochloride molecular weight