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Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 mg | $1,450 | 1-2 weeks | |
200 mg | $1,936 | 1-2 weeks |
Description | GSK 690 (Hydrochloride) is a reversible lysine specific demethylase 1 (LSD1) inhibitor with a Kd value of 9 nM and IC 50 of 37 nM. |
In vitro | GSK690 (1-10 μM) synergizes with JNJ-26481585 to promote cell death across four RMS cell lines (RD, RH30, RMS13, and TE381.T cells), impacting the equilibrium of pro- and antiapoptotic proteins at 1 μM for RD cells and at 10 μM for RH30 cells. This combined treatment triggers caspase-dependent apoptosis at these same concentrations for RD and RH30 cells, respectively, and amplifies JNJ-26481585-induced G2/M phase arrest. |
Molecular Weight | 405.92 |
Formula | C24H24ClN3O |
Cas No. | 2436760-79-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 125 mg/mL (307.94 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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