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GYKI 53655 hydrochloride

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Purity:98.02%

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COA LCMS

GYKI 53655 hydrochloride

Catalog No. T15456Cas No. 143692-48-2

GYKI 53655 hydrochloride (LY300168 hydrochloride) is an antagonist of AMPA and is used in the study of neurological disorders.

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Pack Size	Price	Availability	Quantity
1 mg	$64	In Stock
2 mg	$93	In Stock

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Product Introduction

Bioactivity

Description	GYKI 53655 hydrochloride (LY300168 hydrochloride) is an antagonist of AMPA and is used in the study of neurological disorders.
In vitro	GYKI 53655 hydrochloride inhibited AMPA (10 μM)-mediated responses in recombinant human GluR1 receptors expressed in HEK293 cells and recombinant human GluR4 receptors expressed in HEK293 cells with approximate IC50 values of 6 μM and 5 μM, respectively.[1].
In vivo	GYKI 53655 hydrochloride (2-8 mg/kg) can dose-dependently inhibit or completely abolish AMPA responses in vivo[3].
Alias	GYKI53655 hydrochloride, LY300168 hydrochloride

Chemical Properties

Molecular Weight	388.85
Formula	C19H21ClN4O3
Cas No.	143692-48-2

Storage & Solubility Information

Storage

keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 120 mg/mL (308.60 mM)

H2O: 2 mg/mL (5.14 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.5717 mL	12.8584 mL	25.7169 mL	128.5843 mL
5 mM	0.5143 mL	2.5717 mL	5.1434 mL	25.7169 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2572 mL	1.2858 mL	2.5717 mL	12.8584 mL
20 mM	0.1286 mL	0.6429 mL	1.2858 mL	6.4292 mL
50 mM	0.0514 mL	0.2572 mL	0.5143 mL	2.5717 mL
100 mM	0.0257 mL	0.1286 mL	0.2572 mL	1.2858 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc