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HPN-01
🥰Excellent
Catalog No. T11573Cas No. 928655-63-4
Alias HPN01, HPN 01
HPN-01 (IKK inhibitor XII) is a selective IKK inhibitor that inhibits IKK-α, IKK-β, and IKK-ε. HPN-01 reduces the severity of the disease, attenuates the immune imbalance, and prolongs the lifespan of mice in a model of autoimmune encephalomyelitis, and can be used to study immune disorders.
HPN-01
🥰Excellent
Purity: 98.07%
Catalog No. T11573Alias HPN01, HPN 01Cas No. 928655-63-4
HPN-01 (IKK inhibitor XII) is a selective IKK inhibitor that inhibits IKK-α, IKK-β, and IKK-ε. HPN-01 reduces the severity of the disease, attenuates the immune imbalance, and prolongs the lifespan of mice in a model of autoimmune encephalomyelitis, and can be used to study immune disorders.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $317 | In Stock |
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Purity:98.07%
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Product Introduction
Bioactivity
Chemical Properties
| Description | HPN-01 (IKK inhibitor XII) is a selective IKK inhibitor that inhibits IKK-α, IKK-β, and IKK-ε. HPN-01 reduces the severity of the disease, attenuates the immune imbalance, and prolongs the lifespan of mice in a model of autoimmune encephalomyelitis, and can be used to study immune disorders. |
| Targets&IC50 | IKK2:7 (pIC50), IKK1:6.4 (pIC50), IKKε:4.8(pIC50), IKKβ:7(pIC50), IKKα:6.4(pIC50), IKK-ε:4.8 (pIC50) |
| In vitro | HPN-01 could inhibit the expression of SREBP-1 and SREBP-2 in human primary hepatocytes, and the IC50 values were 1.71 and 3.43, respectively. It is commonly used in the study of nonalcoholic fatty liver disease (NAFLD)[1]. |
| Alias | HPN01, HPN 01 |
| Molecular Weight | 401.87 |
| Formula | C19H16ClN3O3S |
| Cas No. | 928655-63-4 |
| Smiles | NC(=O)c1cc(cc(c1N)-c1ccc(cc1)S(N)(=O)=O)-c1ccc(Cl)cc1 |
| Relative Density. | 1.425 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (199.07 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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