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Intetumumab
🥰Excellent
Catalog No. T76812Cas No. 725735-28-4
Alias CNTO95, CNTO095, CNTO 95, CNTO 095, Anti-Human CD51 Recombinant Antibody
Intetumumab (CNTO 95) is a fully human anti-α(v)-integrin monoclonal antibody that is a radiosensitizer in xenograft tumor-bearing mice, inhibits tumor growth, and reduces lung metastases in the A549 NSCLC xenograft model.
Intetumumab
Intetumumab
🥰Excellent
Catalog No. T76812Alias CNTO95, CNTO095, CNTO 95, CNTO 095, Anti-Human CD51 Recombinant AntibodyCas No. 725735-28-4
Intetumumab (CNTO 95) is a fully human anti-α(v)-integrin monoclonal antibody that is a radiosensitizer in xenograft tumor-bearing mice, inhibits tumor growth, and reduces lung metastases in the A549 NSCLC xenograft model.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $263 | In Stock | |
| 5 mg | $795 | In Stock | |
| 10 mg | $1,350 | In Stock | |
| 25 mg | $1,960 | In Stock | |
| 50 mg | $2,680 | In Stock | |
| 100 mg | $3,650 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Intetumumab (CNTO 95) is a fully human anti-α(v)-integrin monoclonal antibody that is a radiosensitizer in xenograft tumor-bearing mice, inhibits tumor growth, and reduces lung metastases in the A549 NSCLC xenograft model. |
| In vitro | Intetumumab was able to inhibit integrin-mediated attachment of USPC-ARK-3 cells to the hyaluronan matrix and inhibit serum-induced migration of USPC cells at concentrations ranging from 0 to 5 μg/mL and treatment for 20 minutes. [1] |
| In vivo | Intetumumab administered intraperitoneally at a dose of 10 mg/kg to male nude mice was able to reduce the growth of A549 tumors and inhibit their spontaneous lung metastasis, as well as to reduce the number of mice presenting with lung metastases and the number of metastatic lesions per lung. [2] |
| Alias | CNTO95, CNTO095, CNTO 95, CNTO 095, Anti-Human CD51 Recombinant Antibody |
| Molecular Weight | 145.6 (kDa) |
| Cas No. | 725735-28-4 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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