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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $456 | Backorder | |
5 mg | $1,360 | Backorder | |
10 mg | $2,360 | Backorder | |
50 mg | Inquiry | Backorder | |
100 mg | Inquiry | Backorder |
Description | iRucaparib-AP6, a non-trapping PARP1 degrader, blocks both the catalytic activity and scaffolding effects of PARP1. iRucaparib-AP6 is a highly efficient and specific PARP1 degrader based on Rucaparib by using the PROTAC approach. |
In vitro | iRucaparib-AP6 (0-10 μM; 24 hours) decreases PARP-1 levels in a dose-dependent manner, with a half-maximal degrading concentration (DC50) of 82 nM (Dmax = 92%). |
Molecular Weight | 886.96 |
Formula | C46H55FN6O11 |
Cas No. | 2410557-00-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (56.37 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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