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iRucaparib-AP6
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Catalog No. T13737Cas No. 2410557-00-3
iRucaparib-AP6, a non-trapping PARP1 degrader, blocks both the catalytic activity and scaffolding effects of PARP1. iRucaparib-AP6 is a highly efficient and specific PARP1 degrader based on Rucaparib by using the PROTAC approach.
iRucaparib-AP6
😃Good
Catalog No. T13737Cas No. 2410557-00-3
iRucaparib-AP6, a non-trapping PARP1 degrader, blocks both the catalytic activity and scaffolding effects of PARP1. iRucaparib-AP6 is a highly efficient and specific PARP1 degrader based on Rucaparib by using the PROTAC approach.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $456 | Backorder | |
| 5 mg | $1,360 | Backorder | |
| 10 mg | $2,360 | Backorder | |
| 50 mg | Inquiry | Backorder | |
| 100 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | iRucaparib-AP6, a non-trapping PARP1 degrader, blocks both the catalytic activity and scaffolding effects of PARP1. iRucaparib-AP6 is a highly efficient and specific PARP1 degrader based on Rucaparib by using the PROTAC approach. |
| In vitro | iRucaparib-AP6 (0-10 μM; 24 hours) decreases PARP-1 levels in a dose-dependent manner, with a half-maximal degrading concentration (DC50) of 82 nM (Dmax = 92%). |
| Molecular Weight | 886.96 |
| Formula | C46H55FN6O11 |
| Cas No. | 2410557-00-3 |
| Relative Density. | 1.331 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (56.37 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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