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Isorhamnetin-3-O-glucoside

🥰Excellent
Catalog No. T5S1988Cas No. 5041-82-7
Alias Isorhamnetin-3-O-beta-D-Glucoside

Isorhamnetin-3-O-glucoside (Isorhamnetin-3-O-beta-D-Glucoside) inhibits the activity of alpha-glucosidase from rat intestine; it exhibits a potent rat lens aldose reductase (RLAR) inhibition in vitro, its IC(50) being 1.4 microM and has inhibitory effects of sorbitol accumulation, suggests that it is a leading compound for further study as a new drug for the prevention and/or treatment of diabetes and its complications.

Isorhamnetin-3-O-glucoside

Isorhamnetin-3-O-glucoside

🥰Excellent
Purity: 99.81%
Catalog No. T5S1988Alias Isorhamnetin-3-O-beta-D-GlucosideCas No. 5041-82-7
Isorhamnetin-3-O-glucoside (Isorhamnetin-3-O-beta-D-Glucoside) inhibits the activity of alpha-glucosidase from rat intestine; it exhibits a potent rat lens aldose reductase (RLAR) inhibition in vitro, its IC(50) being 1.4 microM and has inhibitory effects of sorbitol accumulation, suggests that it is a leading compound for further study as a new drug for the prevention and/or treatment of diabetes and its complications.
Pack SizePriceAvailabilityQuantity
1 mg$72In Stock
5 mg$247In Stock
10 mg$413In Stock
25 mg$828In Stock
50 mg$1,120In Stock
1 mL x 10 mM (in DMSO)$258In Stock
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Purity:99.81%
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Product Introduction

Bioactivity
Description
Isorhamnetin-3-O-glucoside (Isorhamnetin-3-O-beta-D-Glucoside) inhibits the activity of alpha-glucosidase from rat intestine; it exhibits a potent rat lens aldose reductase (RLAR) inhibition in vitro, its IC(50) being 1.4 microM and has inhibitory effects of sorbitol accumulation, suggests that it is a leading compound for further study as a new drug for the prevention and/or treatment of diabetes and its complications.
In vitro
The inhibitory effects of compounds from Salicornia herbacea (Chenopodiaceae) on rat lens aldose reductase (RLAR) and sorbitol accumulation in streptozotocin-induced diabetic rat tissues were investigated. METHODS AND RESULTS:The various fractions from the MeOH extract of S. herbacea were tested for their effects on RLAR in vitro. Among them, the EtOAc fraction was found to exhibit a potent RLAR inhibition (IC(50)=0.75 microg/ml), from which an active principle as a potent AR inhibitor was isolated and its chemical structure was elucidated as Isorhamnetin-3-O-beta-D-Glucoside (1) by spectral analysis. Compound 1 exhibited a potent RLAR inhibition in vitro, its IC(50) being 1.4 microM. Compound 1, when administered orally at 25 mg/kg in streptozotocin (STZ)-induced diabetic rats, caused not only a significant inhibition of serum glucose concentration but also sorbitol accumulation in the lenses, red blood cells (RBC), and sciatic nerves. CONCLUSIONS:These results indicate that compound 1 from S. herbacea is a leading compound for further study as a new drug for the prevention and/or treatment of diabetes and its complications.
AliasIsorhamnetin-3-O-beta-D-Glucoside
Chemical Properties
Molecular Weight478.4
FormulaC22H22O12
Cas No.5041-82-7
SmilesCOc1cc(ccc1O)-c1oc2cc(O)cc(O)c2c(=O)c1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Relative Density.1.75 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 250 mg/mL (522.58 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0903 mL10.4515 mL20.9030 mL104.5151 mL
5 mM0.4181 mL2.0903 mL4.1806 mL20.9030 mL
10 mM0.2090 mL1.0452 mL2.0903 mL10.4515 mL
20 mM0.1045 mL0.5226 mL1.0452 mL5.2258 mL
50 mM0.0418 mL0.2090 mL0.4181 mL2.0903 mL
100 mM0.0209 mL0.1045 mL0.2090 mL1.0452 mL

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