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Jaspamycin
Catalog No. T11711Cas No. 22242-96-2
Alias 7-CN-7-C-Ino
Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα but exhibits anti-parasite activity and is a potent activator of PKA, binding to the R site (PKAR) with an EC50 of 6.5 nM and a Kd of 8 nM in Trypanosoma brucei.
Jaspamycin
Catalog No. T11711Alias 7-CN-7-C-InoCas No. 22242-96-2
Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα but exhibits anti-parasite activity and is a potent activator of PKA, binding to the R site (PKAR) with an EC50 of 6.5 nM and a Kd of 8 nM in Trypanosoma brucei.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $297 | 6-8 weeks | |
| 25 mg | $987 | 6-8 weeks | |
| 50 mg | $1,360 | 6-8 weeks | |
| 100 mg | $1,860 | 6-8 weeks | |
| 1 mL x 10 mM (in DMSO) | $318 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Jaspamycin (7-CN-7-C-Ino) does not bind with purified human PKARIα but exhibits anti-parasite activity and is a potent activator of PKA, binding to the R site (PKAR) with an EC50 of 6.5 nM and a Kd of 8 nM in Trypanosoma brucei. |
| Targets&IC50 | PKAR (T. b. brucei):6.5 nM (EC50), PKA holoenzyme (T. b. brucei):8 nM (Kd) |
| Alias | 7-CN-7-C-Ino |
| Molecular Weight | 292.25 |
| Formula | C12H12N4O5 |
| Cas No. | 22242-96-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 41.67 mg/mL (142.58 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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